Strilbytska Olha, Koliada Oleksandr, Lushchak Volodymyr, Lushchak Oleh
Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.
Department of Population Genetics, Institute of Food Biotechnology and Genomics NAS of Ukraine, Kyiv, Ukraine.
Curr Neuropharmacol. 2025;23(10):1156-1168. doi: 10.2174/011570159X333438240927103741.
Post-traumatic Stress Disorder (PTSD) is a psychiatric disease that arises in individuals who have experienced a traumatic event such as combat exposure, childhood physical abuse, sexual violence, physical assault, an accident, etc. Being difficult to diagnose and treat, PTSD is actively studied in areas of medicine, psychiatry, biochemistry, and rehabilitation. PTSD is characterized by significant comorbidity and is accompanied by depression and anxiety. Current treatment strategies for PTSD symptoms include psychotherapy and medications. Naturally derived compounds can offer therapeutic benefits for mood disorders without unpleasant side effects. Bioactive compounds found in food exhibit beneficial effects such as antioxidant, anti-inflammatory, and neuroprotective activities. Here, we describe the promising therapeutic benefits of a number of bioactive substances that have been evaluated in a variety of animal models and human experimental studies. Anxiolytic, antidepressant, and antidementia activities of bioactive compounds emphasize their potential for treating PTSD comorbidities. Hypothetical mechanisms of actions are also discussed, providing insights into their potential for human mental health.
创伤后应激障碍（PTSD）是一种精神疾病，发生于经历过创伤性事件的个体，如战斗暴露、童年身体虐待、性暴力、身体攻击、事故等。由于难以诊断和治疗，医学、精神病学、生物化学和康复领域都在积极研究PTSD。PTSD的特点是显著的共病性，并伴有抑郁和焦虑。目前针对PTSD症状的治疗策略包括心理治疗和药物治疗。天然衍生化合物可为情绪障碍提供治疗益处，且无不良副作用。食物中发现的生物活性化合物具有抗氧化、抗炎和神经保护等有益作用。在此，我们描述了多种生物活性物质在各种动物模型和人体实验研究中所评估出的有前景的治疗益处。生物活性化合物的抗焦虑、抗抑郁和抗痴呆活性强调了它们治疗PTSD共病的潜力。还讨论了假设的作用机制，为它们对人类心理健康的潜力提供了见解。
