Rangseekajee Poonsri, Piyavhatkul Nawanant, Wattanathorn Jintanaporn, Thukham-Mee Wipawee, Paholpak Pongsatorn
Research Institute for High Human Performance and Health Promotion, Khon Kaen University, Khon Kaen 40000, Thailand.
Brain and Mind Wellness Research Group, Khon Kaen University, Khon Kaen 40000, Thailand.
Nutr Res Pract. 2024 Feb;18(1):110-118. doi: 10.4162/nrp.2024.18.1.110. Epub 2024 Jan 16.
BACKGROUND/OBJECTIVES: Depression and anxiety are common mental health problems. Anthocyanins from berries might have an inhibitory effect on monoamine oxidase (MAO) enzymes and alleviate various mood and anxiety symptoms. This study examined the effects of a daily supplement of an anthocyanin-rich product on mental health problems.
SUBJECTS/METHODS: This study was a secondary analysis from a randomized, 6-week, open-label trial in 300 healthy participants aged 18-60 years who consumed 1 or 2 servings of anthocyanin-rich mulberry milk daily. The General Health Questionnaire-28 (GHQ-28) and Hospital Anxiety and Depression Scale (HADS) were used to monitor mental health problems. In addition, the saliva activity levels of MAO-A, MAO-B, and cortisol were examined at the baseline and after 6 weeks.
The total scores of the GHQ-28 and HADS and all their subscales decreased in both groups (all < 0.05). The cortisol, MAO-A, and MAO-B activities decreased significantly (all <0.05), but there were no significant differences between the groups (all > 0.05). Significant correlations were noted between the decreased activity level of MAO-A enzyme and decreased scores from the GHQ-28 somatic subscale and the HADS depression subscale (all < 0.05).
Daily consumption of anthocyanin-rich mulberry milk possibly improves mental health problems by reducing depressive and anxiety symptoms in the working population. The suppression of MAO-A activity is a possible underlying mechanism.
Thai Clinical Trial Registration: #TCTR20201031002.
背景/目的：抑郁和焦虑是常见的心理健康问题。浆果中的花青素可能对单胺氧化酶（MAO）具有抑制作用，并减轻各种情绪和焦虑症状。本研究探讨了每日补充富含花青素的产品对心理健康问题的影响。
受试者/方法：本研究是对一项随机、为期6周的开放标签试验的二次分析，该试验纳入了300名年龄在18至60岁之间的健康参与者，他们每天食用1或2份富含花青素的桑椹奶。使用一般健康问卷-28（GHQ-28）和医院焦虑抑郁量表（HADS）来监测心理健康问题。此外，在基线和6周后检测了MAO-A、MAO-B和皮质醇的唾液活性水平。
两组的GHQ-28和HADS总分及其所有子量表得分均下降（均P<0.05）。皮质醇、MAO-A和MAO-B活性显著下降（均P<0.05），但两组之间无显著差异（均P>0.05）。MAO-A酶活性水平的降低与GHQ-28躯体子量表和HADS抑郁子量表得分的降低之间存在显著相关性（均P<0.05）。
每日食用富含花青素的桑椹奶可能通过减轻工作人群的抑郁和焦虑症状来改善心理健康问题。MAO-A活性的抑制可能是潜在机制。
泰国临床试验注册：#TCTR20201031002。
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