Page Muskan, Bagali Shrilaxmi, Das Kusal K
Allied Health Science, BLDE (Deemed to be University), Vijayapura, IND.
Physiology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND.
Cureus. 2024 Aug 31;16(8):e68342. doi: 10.7759/cureus.68342. eCollection 2024 Aug.
The known impact of diet on the pathophysiology of various chronic diseases and the current dietary transition in the country make it essential to assess the influence of dietary patterns specific to this region on inflammation, oxidative stress, and endothelial functions.
This study compared oxidative stress, inflammation, and endothelial functions among vegetarians and non-vegetarians in Vijayapura, Karnataka, India.
The present cross-sectional comparative study involved apparently healthy vegetarians (n=35) and non-vegetarians (n=35) aged 20-40. The anthropometric measurements like height (cm) and weight (kg) were recorded, and the BMI was calculated. The physiological parameters like systolic and diastolic blood pressure and pulse rate were recorded. Serum high-sensitivity C-reactive protein (hs-CRP), serum malondialdehyde (MDA), and serum nitric oxide (NO) were estimated as markers of inflammation, oxidative stress, and endothelial function, respectively. Statistical analysis was done using SPSS Statistics version 20.0 (IBM Corp. Released 2011. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp.).
The average age of vegetarians and non-vegetarians was 25.22 ± 7.63 years and 25.60 ± 5.64 years, respectively. Anthropometric and physiological parameters were comparable between the two groups. However, there was a trend for higher mean body weight among non-vegetarians (53.94± 6.73 vs. 57.22±7.18) with a marginal non-statistically significant p-value (p=0.052). Vegetarians showed significantly higher serum MDA levels than non-vegetarians (2.14 (0.93-2.91) vs. 0.64 (0.35-1.32); p=0.000), while hs-CRP (vegetarians - 0.01 (0.005-0.034) vs. non-vegetarians - 0.03 (0.01-0.04); p=0.18) and serum NO levels (vegetarians - 6.72 (5.46-8.39) vs. non-vegetarians - 5.43 (2.87-9.16); p=0.215) were similar in both groups.
The results were intriguing and contrasting, as serum MDA is remarkably higher among vegetarians than non-vegetarians, pointing toward greater oxidative stress among the former and possibly indicating a dietary imbalance among vegetarians, which needs further exploration.
饮食对各种慢性疾病病理生理学的已知影响以及该国当前的饮食转变，使得评估该地区特定饮食模式对炎症、氧化应激和内皮功能的影响至关重要。
本研究比较了印度卡纳塔克邦维贾亚普拉市素食者和非素食者的氧化应激、炎症和内皮功能。
本横断面比较研究纳入了20 - 40岁的明显健康的素食者（n = 35）和非素食者（n = 35）。记录身高（厘米）和体重（千克）等人体测量数据，并计算体重指数。记录收缩压、舒张压和脉搏率等生理参数。分别测定血清高敏C反应蛋白（hs-CRP）、血清丙二醛（MDA）和血清一氧化氮（NO）作为炎症、氧化应激和内皮功能的标志物。使用SPSS Statistics 20.0版（IBM公司。2011年发布。适用于Windows的IBM SPSS Statistics，版本20.0。纽约州阿蒙克：IBM公司）进行统计分析。
素食者和非素食者的平均年龄分别为25.22±7.63岁和25.60±5.64岁。两组的人体测量和生理参数具有可比性。然而，非素食者的平均体重有更高的趋势（53.94±6.73对57.22±7.18），p值边缘无统计学意义（p = 0.052）。素食者的血清MDA水平显著高于非素食者（2.14（0.93 - 2.91）对0.64（0.35 - 1.32）；p = 0.000），而hs-CRP（素食者 - 0.01（0.005 - 0.034）对非素食者 - 0.03（0.01 - 0.04）；p = 0.18）和血清NO水平（素食者 - 6.72（5.46 - 8.39）对非素食者 - 5.43（2.87 - 9.16）；p = 0.215）在两组中相似。
结果令人感兴趣且相互矛盾，因为素食者的血清MDA显著高于非素食者，这表明前者的氧化应激更大，可能表明素食者存在饮食不平衡，这需要进一步探索。
