Shimazaki Shunsuke, Sato Junichi
Department of Paediatrics, Funabashi Municipal Medical Center, Funabashi, JPN.
Cureus. 2024 Sep 1;16(9):e68361. doi: 10.7759/cureus.68361. eCollection 2024 Sep.
This case report describes the rare occurrence of idiopathic juvenile osteoporosis (IJO) in an 11-year-old boy with bone fragility and fractures, particularly in the thoracic and lumbar vertebrae. After excluding discernible underlying causes, the diagnosis was confirmed using clinical and radiological assessments. Treatment commenced with oral bisphosphonates, leading to notable bone mineral density (BMD) improvements and the absence of subsequent fractures. IJO presents diagnostic challenges owing to its multifaceted nature, necessitating the exclusion of other common causes of pediatric osteoporosis. Although the pathophysiology of IJO remains poorly understood, this case underscores the potential efficacy of bisphosphonate therapy in managing the condition and improving patient outcomes. Notably, the patient's symptoms ameliorated as puberty commenced, aligning with the typical IJO patterns reported in the literature. Although the long-term impact of bisphosphonate treatment in pediatric IJO cases warrants further investigation, this case exemplifies the potential to enhance the quality of life of affected individuals.
本病例报告描述了一名11岁男孩罕见的特发性青少年骨质疏松症（IJO），该男孩存在骨脆性和骨折问题，尤其是胸椎和腰椎骨折。在排除可识别的潜在病因后，通过临床和放射学评估确诊。治疗从口服双膦酸盐开始，使骨矿物质密度（BMD）显著改善，且随后未再发生骨折。IJO因其多方面的性质而带来诊断挑战，需要排除小儿骨质疏松症的其他常见病因。尽管IJO的病理生理学仍知之甚少，但该病例强调了双膦酸盐治疗在控制病情和改善患者预后方面的潜在疗效。值得注意的是，随着青春期开始，患者症状有所改善，这与文献报道的典型IJO模式相符。尽管双膦酸盐治疗对小儿IJO病例的长期影响值得进一步研究，但该病例例证了提高受影响个体生活质量的潜力。
