An Dayeong, Shin Joon Soo, Bae Nanyoung, Seo Sang Won, Na Duk L
Department of Neurology, Happymind Clinic, Seoul, Korea.
Beaubrain Healthcare Co., LTD., Seoul, Korea.
J Korean Med Sci. 2024 Sep 30;39(37):e247. doi: 10.3346/jkms.2024.39.e247.
As society ages, the incidence of Alzheimer's disease and other dementias has surged, highlighting the importance of early dementia diagnosis. The Seoul Cognitive Status Test (SCST), a digital neuropsychological test, is designed for the early detection of cognitive impairment and has been standardized to establish reliability and validity. This study aims to verify whether the SCST effectively discriminates between groups based on three cognitive statuses (subjective cognitive decline [SCD], mild cognitive impairment [MCI], Dementia) in a large sample. We also seek to determine whether the SCST discriminates between individuals with three different cognitive statuses as defined by the Cognitive Dementia Rating (CDR).
We enrolled 254 participants from a dementia clinic who underwent a comprehensive neuropsychological battery (Seoul Neuropsychological Screening Battery-II) during the dementia evaluation by experienced neurologists (55 with SCD, 126 with MCI, 73 with dementia). In addition, the degree of cognitive decline in participants was classified by CDR level (186 with CDR 0.5, 52 with CDR 1, 15 with CDR 2). One-way analysis of variance was used to compare SCST scores according to each of the three cognitive status groups and CDR levels.
The SCST total score, cognitive domain scores (attention, language, visuospatial function, memory, executive function), and most of the subtest scores decreased significantly in the order of SCD, MCI and dementia. Likewise, the differences in SCST scores between CDR levels were significant, particularly in distinguishing between CDR 0.5 and CDR 1.
This study reaffirmed that the SCST can significantly discriminate between groups of individuals with SCD, MCI, and dementia based on a large sample. Furthermore, differences in SCT scores were found across the levels of CDR, confirming the clinical utility of the SCST. These findings suggest that the SCST is an efficient and useful neuropsychological test for the sensitive detection of early cognitive impairment.
随着社会老龄化，阿尔茨海默病和其他痴呆症的发病率激增，凸显了早期痴呆诊断的重要性。首尔认知状态测试（SCST）是一种数字神经心理学测试，旨在早期检测认知障碍，并已标准化以确立其可靠性和有效性。本研究旨在验证SCST在大样本中能否根据三种认知状态（主观认知下降[SCD]、轻度认知障碍[MCI]、痴呆）有效区分不同组。我们还试图确定SCST能否区分由认知痴呆评定量表（CDR）定义的三种不同认知状态的个体。
我们从一家痴呆症诊所招募了254名参与者，他们在由经验丰富的神经科医生进行痴呆症评估期间接受了全面的神经心理学测试组合（首尔神经心理学筛查组合-II）（55名SCD患者、126名MCI患者、73名痴呆患者）。此外，参与者的认知下降程度按CDR水平分类（186名CDR 0.5患者、52名CDR 1患者、15名CDR 2患者）。采用单因素方差分析比较根据三种认知状态组和CDR水平划分的SCST分数。
SCST总分、认知领域分数（注意力、语言、视觉空间功能、记忆、执行功能）以及大多数子测试分数按SCD、MCI和痴呆的顺序显著下降。同样，CDR水平之间的SCST分数差异显著，特别是在区分CDR 0.5和CDR 1方面。
本研究再次证实，基于大样本，SCST能够显著区分SCD、MCI和痴呆个体组。此外，发现SCST分数在CDR水平之间存在差异，证实了SCST的临床实用性。这些发现表明，SCST是一种用于敏感检测早期认知障碍的高效且有用的神经心理学测试。
