Pokharel Asmita, Pokhrel Buddhi, Bhattarai Richa, Khanal Madhav
Nepal Medical College Teaching Hospital, Atterkhel, Kathmandu, Nepal.
Universal College of Medical Sciences, Bhairahawa, Rupandehi, Nepal.
JNMA J Nepal Med Assoc. 2024 May 31;62(274):382-386. doi: 10.31729/jnma.8616.
Liver is most commonly affected in dengue often resulting in changes in the liver function test parameters. Alterations in hematological parameters are also reported which could serve as early prognostic markers especially in resource limited settings where serological tests for the diagnosis of dengue is not available. This study aims to analyze liver function test and hematological parameter changes in dengue infected patients.
A descriptive cross-sectional study was conducted from December 2022 to October 2023 in serologically dengue positive patients. Liver function parameters and blood parameters were analyzed from 220 patients. The purposive sampling technique was employed during the selection of participants.
Out of 220 study participants, 113 (51.36%) were males and 107 (49.64%) were females. The median age of the participants was 35 years (IQR: 26 - 48 years). Elevated serum AST and ALT levels were present in 121 (55%) and 80 (36.36%) of the participants respectively. Thrombocytopenia and leukopenia were observed in 92 (41.82%) and 88 (40%) of the study participants respectively. The median hemoglobin level was 14.4 (IQR: 13-15.47) g/dl. Low hemoglobin level was found in 31 (14.09%) participants. The median red blood cell count was 4.91 (IQR: 4.49 - 5.28) millions/mm3 with decreased red blood cell count noted in 27 (12.27%) participants.
Increased serum transaminases levels, thrombocytopenia and leukopenia are common laboratory findings in dengue patients.
肝脏是登革热最常受累的器官，常导致肝功能检查参数发生变化。也有报道称血液学参数发生改变，这可作为早期预后标志物，尤其是在资源有限且无法进行登革热血清学诊断检测的环境中。本研究旨在分析登革热感染患者的肝功能检查及血液学参数变化。
2022年12月至2023年10月，对血清学检测登革热呈阳性的患者进行了一项描述性横断面研究。分析了220例患者的肝功能参数和血液参数。在选择参与者时采用了目的抽样技术。
220名研究参与者中，113名（51.36%）为男性，107名（49.64%）为女性。参与者的中位年龄为35岁（四分位间距：26 - 48岁）。分别有121名（55%）和80名（36.36%）参与者血清AST和ALT水平升高。分别有92名（41.82%）和88名（40%）研究参与者出现血小板减少和白细胞减少。血红蛋白水平中位数为14.4（四分位间距：13 - 15.47）g/dl。31名（14.09%）参与者血红蛋白水平较低。红细胞计数中位数为4.91（四分位间距：4.49 - 5.28）百万/mm³，27名（12.27%）参与者红细胞计数降低。
血清转氨酶水平升高、血小板减少和白细胞减少是登革热患者常见的实验室检查结果。
