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一心同体:RAS 二聚体之争仍在继续。

Two hearts beat as one: the debate over RAS dimers continues.

机构信息

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

出版信息

Trends Biochem Sci. 2024 Nov;49(11):933-935. doi: 10.1016/j.tibs.2024.09.005. Epub 2024 Oct 1.

Abstract

A recent report by Yun et al. describes the detection of RAS dimers using intact mass spectrometry and investigates the role that membrane lipids, nucleotide state, and binding partners have in their formation.

摘要

云等人最近的一份报告描述了使用完整质谱法检测 RAS 二聚体,并研究了膜脂、核苷酸状态和结合伴侣在其形成中的作用。

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Two hearts beat as one: the debate over RAS dimers continues.一心同体:RAS 二聚体之争仍在继续。
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本文引用的文献

1
Capturing RAS oligomerization on a membrane.在膜上捕获 RAS 寡聚体。
Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2405986121. doi: 10.1073/pnas.2405986121. Epub 2024 Aug 15.
7
The Frequency of Ras Mutations in Cancer.癌症中 Ras 突变的频率。
Cancer Res. 2020 Jul 15;80(14):2969-2974. doi: 10.1158/0008-5472.CAN-19-3682. Epub 2020 Mar 24.
8
Ras-Mediated Activation of the Raf Family Kinases.Ras 介导的 Raf 家族激酶的激活。
Cold Spring Harb Perspect Med. 2019 Jan 2;9(1):a033746. doi: 10.1101/cshperspect.a033746.
9
Ras and the Plasma Membrane: A Complicated Relationship.Ras 与质膜:复杂的关系。
Cold Spring Harb Perspect Med. 2018 Oct 1;8(10):a031831. doi: 10.1101/cshperspect.a031831.
10
RAS Proteins and Their Regulators in Human Disease.人类疾病中的RAS蛋白及其调节因子
Cell. 2017 Jun 29;170(1):17-33. doi: 10.1016/j.cell.2017.06.009.

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