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埃塞俄比亚阿达玛成年 2 型糖尿病患者中的糖尿病周围神经病变:基于医疗机构的研究。

Diabetic peripheral neuropathy among adult type 2 diabetes patients in Adama, Ethiopia: health facility-based study.

机构信息

Department of Medicine, Adama General Hospital and Medical College, Adama, Ethiopia.

Department of Public Health, Adama Hospital Medical College, Adama, Ethiopia.

出版信息

Sci Rep. 2024 Feb 15;14(1):3844. doi: 10.1038/s41598-024-53951-y.

Abstract

Diabetic peripheral neuropathy is the most prominent microvascular complication of diabetes mellitus and the leading cause of ulceration, amputation, and extended hospitalization. Evidence regarding the magnitude and factors associated with diabetic peripheral neuropathy is not well documented in Ethiopia, particularly in the study area. A facility-based cross-sectional study was conducted among 293 adult type 2 diabetic patients who were on treatment and follow-up from May to June 31, 2023. To select participants in the study, a systematic random sampling method was utilized. Data were collected using semi-structured questionnaires and medical record reviews. The Michigan Neuropathy Screening Instrument (MNSI) was employed to assess diabetic peripheral neuropathy. To model the association between diabetic peripheral neuropathy and independent variables, binary logistic regression model was used. An adjusted odds ratio with a 95% confidence interval was used to estimate the association and statistical significance was proclaimed at a p-value < 0.05. The magnitude of diabetic peripheral neuropathy was 14.3% (95% CI 10.4-18.0). It was 13.4% (95% CI 8.4-19.1) among males and 15.4% (95% CI 10.1-22.2) among females. Age above 60 years (AOR = 5.06, 95% CI 1.60-15.96), being rural resident (AOR = 2.41; 95% CI 1.15-5.06), duration of diabetes above 5 years (AOR = 2.48, 95% CI 1.16-5.27) and having comorbid hypertension (AOR = 2.56, 95% CI 1.24-5.28) were independently associated with diabetic peripheral neuropathy. One in seven adult type 2 diabetes patients in the study area had diabetic peripheral neuropathy. Factors such as age, place of residence, duration of diabetes, and comorbid hypertension showed positive associations with diabetic peripheral neuropathy. Thus, it is imperative to give special consideration to diabetic patients who are elderly, living in rural areas, experiencing a prolonged duration of diabetes, or dealing with comorbid hypertension.

摘要

糖尿病周围神经病变是糖尿病最突出的微血管并发症,也是溃疡、截肢和住院时间延长的主要原因。在埃塞俄比亚,特别是在研究区域,有关糖尿病周围神经病变的严重程度和相关因素的证据尚未得到充分记录。本项基于医疗机构的横断面研究于 2023 年 5 月至 6 月 31 日期间,在 293 名正在接受治疗和随访的成年 2 型糖尿病患者中进行。为了在研究中选择参与者,采用了系统随机抽样方法。使用半结构式问卷和病历回顾收集数据。采用密歇根州周围神经病变筛查工具(MNSI)评估糖尿病周围神经病变。为了对糖尿病周围神经病变与自变量之间的关联进行建模,采用二元逻辑回归模型。使用调整后的优势比(95%置信区间)来估计关联,p 值<0.05 表示具有统计学意义。糖尿病周围神经病变的发生率为 14.3%(95%CI 10.4-18.0)。男性为 13.4%(95%CI 8.4-19.1),女性为 15.4%(95%CI 10.1-22.2)。年龄在 60 岁以上(AOR=5.06,95%CI 1.60-15.96)、农村居民(AOR=2.41;95%CI 1.15-5.06)、糖尿病病程超过 5 年(AOR=2.48,95%CI 1.16-5.27)和合并高血压(AOR=2.56,95%CI 1.24-5.28)与糖尿病周围神经病变独立相关。研究地区每 7 名成年 2 型糖尿病患者中就有 1 名患有糖尿病周围神经病变。年龄、居住地、糖尿病病程和合并高血压等因素与糖尿病周围神经病变呈正相关。因此,必须特别关注年龄较大、居住在农村地区、糖尿病病程较长或合并高血压的糖尿病患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58c7/10869338/197ee935062c/41598_2024_53951_Fig1_HTML.jpg

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