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呼吸道暴露期间[具体因素]对氧化锌纳米颗粒生物毒性的影响。 （注：原文中“Effect of on”中间缺少具体内容）

Effect of on biological toxicity of zinc oxide nanoparticles during respiratory exposure.

作者信息

Yao Jingjing, Yang Wanqing, Tang Liang, Yang Dicheng, Xu Yan, Zhu Shenmin, Zhu Jun

机构信息

State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University Shanghai 200240 People's Republic of China

Department of Orthopedic Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine 1111 XianXia Road Shanghai 200336 People's Republic of China.

出版信息

RSC Adv. 2024 Oct 2;14(43):31360-31366. doi: 10.1039/d4ra03738c. eCollection 2024 Oct 1.

DOI:10.1039/d4ra03738c
PMID:39359342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11445702/
Abstract

Although zinc oxide nanoparticles (ZnO NPs) with distinct physicochemical properties have attracted great attention, the application of ZnO NPs is still limited due to their potential biotoxicity. In this work, ZnO- (PS) NPs are synthesized to overcome this challenge. The ZnO NPs stably combine with PS according to microstructural observation, particle size distribution, zeta potential results and Fourier transform infrared spectroscopy analysis. The cytotoxicity of ZnO NPs is alleviated by combining them with PS as a consequence of the diminished generation of reactive oxygen species and reinforced superoxide dismutase activity. Furthermore, the respiratory index and histopathologic results of mice exposed to NPs manifest that the pulmonary dysfunction caused by ZnO NPs is avoided in the ZnO-PS NPs group. This study provides the foundations for the amelioration and universal utilization of ZnO NPs and emphasizes the potential of ZnO-PS NPs in biomedical applications.

摘要

尽管具有独特物理化学性质的氧化锌纳米颗粒（ZnO NPs）已引起广泛关注，但由于其潜在的生物毒性，ZnO NPs的应用仍然受到限制。在这项工作中，合成了ZnO-(PS) NPs以克服这一挑战。根据微观结构观察、粒度分布、zeta电位结果和傅里叶变换红外光谱分析，ZnO NPs与PS稳定结合。由于活性氧生成减少和超氧化物歧化酶活性增强，ZnO NPs与PS结合后其细胞毒性得到缓解。此外，暴露于纳米颗粒的小鼠的呼吸指数和组织病理学结果表明，ZnO-PS NPs组避免了由ZnO NPs引起的肺功能障碍。本研究为ZnO NPs的改善和广泛应用提供了基础，并强调了ZnO-PS NPs在生物医学应用中的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cd/11445702/35cd008ad4d3/d4ra03738c-f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cd/11445702/35cd008ad4d3/d4ra03738c-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cd/11445702/8950ed17deda/d4ra03738c-f1.jpg
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