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里海东南岸地区的骨质疏松症与肥胖症及其与伊朗骨质疏松症患病率的关系。

Osteoporosis and obesity in the South East of Caspian Seashore and its relationship to osteoporosis prevalence in Iran.

作者信息

Malekzadeh Shafaroudi Majid, Rezaei Nourollah, Mohammadnejiad Behrooz, Usefi Gholamali, Malekzadeh Shafaroudi Ali

机构信息

Immunogenetic Research Center (IRC), Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Department of Anatomy and Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

出版信息

Caspian J Intern Med. 2024 Aug 30;15(4):629-635. doi: 10.22088/cjim.15.4.629. eCollection 2024 Fall.

DOI:10.22088/cjim.15.4.629
PMID:39359434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11444095/
Abstract

BACKGROUND

Osteoporosis is the most common metabolic bone disease that begins with a decrease in bone mass and deterioration in the micro-architecture of the bone tissue, making the bones thinner and susceptible to fragility. A comprehensive estimation of the prevalence of osteoporosis in provinces of Iran seems to be necessary.

METHODS

This study was a descriptive-analytical study. The study population included 518 people aged 30-65 years including 297 males and 221 females to measure their bone density. The data collection method was through BMD measurement using Dual-Energy X-ray Absorptiometry (DXA) method. All obtained data stored in the SPSS-16 database and statistically analyzed. The data analyzed using analytical, statistical methods. The significance level of the test was considered to be P≤0.05.

RESULTS

In the present study, according to BMI status, 45.2% of the patients were obese, 38.2% were overweight. Despite the general belief that increasing in weight can be associated with an increase in bone mass, the present research revealed that nearly 35.9% of the research population, suffered obesity and osteoporosis at the same time. Metargression analysis of data from different studies have illustrated that changing in frequency of osteoporosis as an oriented change in prevalence of osteoporosis from west to east and south to north (P≤0.05).

CONCLUSION

Iran society is under concern to more osteoporosis in the coming years at young and old ages which doubled with severe decline in growth rate of population from 3.7% to 0.63% in 2022. This can increase older people ratio over 30% in 2050.

摘要

背景

骨质疏松症是最常见的代谢性骨病,始于骨量减少和骨组织微结构退化,使骨骼变薄并易发生骨折。全面估计伊朗各省骨质疏松症的患病率似乎很有必要。

方法

本研究为描述性分析研究。研究人群包括518名年龄在30 - 65岁之间的人,其中男性297名,女性221名,以测量他们的骨密度。数据收集方法是使用双能X线吸收法(DXA)测量骨密度。所有获得的数据存储在SPSS - 16数据库中并进行统计分析。使用分析性统计方法对数据进行分析。检验的显著性水平被认为是P≤0.05。

结果

在本研究中,根据体重指数(BMI)状况,45.2%的患者肥胖,38.2%超重。尽管普遍认为体重增加可能与骨量增加有关,但本研究表明,近35.9%的研究人群同时患有肥胖症和骨质疏松症。对不同研究数据的Meta回归分析表明,骨质疏松症的发生率从西向东、从南向北呈定向变化(P≤0.05)。

结论

伊朗社会未来几年在年轻和老年人群中都面临着更多骨质疏松症的问题,2022年人口增长率从3.7%急剧下降到0.63%,这一情况会加剧。到2050年,这可能使老年人比例增加超过30%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf8/11444095/9796b5f3bb56/cjim-15-629-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf8/11444095/2a3fa804315d/cjim-15-629-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf8/11444095/bd2c7d8ac040/cjim-15-629-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf8/11444095/9796b5f3bb56/cjim-15-629-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf8/11444095/2a3fa804315d/cjim-15-629-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf8/11444095/bd2c7d8ac040/cjim-15-629-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf8/11444095/9796b5f3bb56/cjim-15-629-g003.jpg

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