Tehrani Fleur T, Roum James H
Department of Electrical and Computer Engineering California State University Fullerton California USA.
School of Medicine University of California Irvine California USA.
Healthc Technol Lett. 2024 May 26;11(5):283-288. doi: 10.1049/htl2.12087. eCollection 2024 Oct.
The purpose of this study was to investigate the effectiveness of two non-invasive mechanical ventilation (NIV) modalities to treat sleep apnea: (1) Average Volume Assured Pressure Support (AVAPS) NIV, and (2) Pressure Support (PS) NIV with Continuously Calculated Average Required Ventilation (CCARV). Two detailed (previously developed and tested) simulation models were used to assess the effectiveness of the NIV modalities. One simulated subjects without chronic obstructive pulmonary disease (COPD), and the other simulated patients with COPD. Sleep apnea was simulated in each model (COPD and Non-COPD), and the ability of each NIV modality to normalize breathing was measured. In both NIV modalities, a low level continuous positive airway pressure was used and a backup respiratory rate was added to the algorithm in order to minimize the respiratory work rate. Both modalities could help normalize breathing in response to an episode of sleep apnea within about 5 min (during which time blood gases were within safe limits). AVAPS NIV and PS NIV with CCARV have potential value to be used for treatment of sleep apnea. Clinical evaluations are needed to fully assess the effectiveness of these NIV modalities.
本研究的目的是调查两种无创机械通气（NIV）模式治疗睡眠呼吸暂停的有效性：（1）定容压力支持（AVAPS）无创通气，以及（2）具有连续计算平均所需通气量（CCARV）的压力支持（PS）无创通气。使用两个详细的（先前开发并经过测试的）模拟模型来评估无创通气模式的有效性。一个模拟无慢性阻塞性肺疾病（COPD）的受试者，另一个模拟患有COPD的患者。在每个模型（COPD和非COPD）中模拟睡眠呼吸暂停，并测量每种无创通气模式使呼吸正常化的能力。在两种无创通气模式中，均使用低水平持续气道正压，并在算法中添加备用呼吸频率，以尽量降低呼吸功。两种模式均可在约5分钟内（在此期间血气处于安全范围内）帮助应对睡眠呼吸暂停发作使呼吸正常化。AVAPS无创通气和具有CCARV的PS无创通气在治疗睡眠呼吸暂停方面具有潜在价值。需要进行临床评估以全面评估这些无创通气模式的有效性。
