Tehrani Fleur T, Roum James H
Department of Electrical and Computer Engineering California State University Fullerton California USA.
School of Medicine University of California Irvine California USA.
Healthc Technol Lett. 2023 Jun 8;10(4):80-86. doi: 10.1049/htl2.12048. eCollection 2023 Aug.
Chronic obstructive pulmonary disease (COPD) affects the lives of millions of patients worldwide. Patients with advanced COPD may require non-invasive ventilation (NIV) to support the resultant deficiencies of the respiratory system. The purpose of this study was to evaluate the effects of varying the continuous positive airway pressure (CPAP) and oxygen supplementation components of NIV on simulated COPD patients by using an established and detailed model of the human respiratory system. The model used in the study simulates features of advanced COPD including the effects on the changes in ventilation control, increases in respiratory dead space and airway resistance, and the acid-base shifts in the blood seen in these patients over time. The results of the study have been compared with and found to be in general agreement with available clinical data. Our results demonstrate that under non-emergency conditions, low levels of oxygen supplementation combined with low levels of CPAP therapy seem to improve hypoxemia and hypercapnia in the model, whereas prolonged high-level CPAP and moderate-to-high levels of oxygen supplementation do not. The authors conclude that such modelling may be useful to help guide beneficial interventions for COPD patients using NIV.
慢性阻塞性肺疾病（COPD）影响着全球数百万患者的生活。晚期慢性阻塞性肺疾病患者可能需要无创通气（NIV）来支持呼吸系统由此产生的功能缺陷。本研究的目的是通过使用已建立的详细人体呼吸系统模型，评估改变无创通气的持续气道正压（CPAP）和氧补充成分对模拟慢性阻塞性肺疾病患者的影响。该研究中使用的模型模拟了晚期慢性阻塞性肺疾病的特征，包括对通气控制变化、呼吸死腔增加和气道阻力增加的影响，以及这些患者随时间推移出现的血液酸碱变化。研究结果已与现有临床数据进行比较，并发现总体上一致。我们的结果表明，在非紧急情况下，低水平氧补充与低水平CPAP治疗相结合似乎能改善模型中的低氧血症和高碳酸血症，而长时间的高水平CPAP和中高水平氧补充则不能。作者得出结论，这种建模可能有助于指导使用无创通气对慢性阻塞性肺疾病患者进行有益的干预。
