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用紫外线辐射对呼吸器进行消毒

Disinfection of Respirators with Ultraviolet Radiation.

作者信息

Poster Dianne L, Hardwick Matthew, Miller C Cameron, Riley Michael A, Rodrigo W W Shanaka I, Vladar Andras E, Wright John D, Zangmeister Christopher D, Zarobila Clarence, Starkweather Jeremy, Wynne John, Yilzarde Jason

机构信息

National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

ResInnova Laboratories, Rockville, MD 20857, USA.

出版信息

J Res Natl Inst Stand Technol. 2022 Mar 25;126:126058. doi: 10.6028/jres.126.058. eCollection 2021.

Abstract

Data for interpreting virus inactivation on N95 face filtering respirators (FFRs) by ultraviolet (UV) radiation are important in developing UV strategies for N95 FFR disinfection and reuse for any situation, whether it be everyday practices, contingency planning for expected shortages, or crisis planning for known shortages. Data regarding the integrity, form, fit, and function of N95 FFR materials following UV radiation exposure are equally important. This article provides these data for N95 FFRs following UV-C irradiation (200 nm to 280 nm) in a commercial UV-C enclosure. Viral inactivation was determined by examining the inactivation of OC43, a betacoronavirus, inoculated on N95 FFRs. Different metrological approaches were used to examine irradiated N95 FFRs to determine if there were any discernible physical differences between non-irradiated N95 FFRs and those irradiated using the UV-C enclosure. Material integrity was examined using high-resolution scanning electron microscopy. Form, fit, and function were examined using flow resistance, tensile strength, and particle filtration measurements. A separate examination of filter efficiency, fit, and strap tensile stress measurements was performed by the National Personal Protective Technology Laboratory. Data from these metrological examinations provide evidence that N95 FFR disinfection and reuse using the UV-C enclosure can be effective.

摘要

对于制定N95口罩式过滤呼吸器(FFR)紫外线(UV)消毒及重复使用策略而言,无论是日常使用、应对预期短缺的应急计划,还是针对已知短缺的危机预案,阐释紫外线辐射对N95 FFR病毒灭活效果的数据都至关重要。紫外线辐射后N95 FFR材料的完整性、形状、贴合度及功能等方面的数据同样重要。本文提供了在商用紫外线C(UV-C,200纳米至280纳米)封闭装置中对N95 FFR进行UV-C辐照后的相关数据。通过检测接种在N95 FFR上的β冠状病毒OC43的灭活情况来确定病毒灭活效果。采用不同的计量方法检测经辐照的N95 FFR,以确定未辐照的N95 FFR与使用UV-C封闭装置辐照后的N95 FFR之间是否存在明显的物理差异。使用高分辨率扫描电子显微镜检测材料完整性。通过气流阻力、拉伸强度及颗粒过滤测量来检测形状、贴合度及功能。美国国家个人防护技术实验室对过滤效率、贴合度及系带拉伸应力测量进行了单独检测。这些计量检测的数据证明,使用UV-C封闭装置对N95 FFR进行消毒及重复使用是有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bec/11415071/d21c6212e33c/jres-fig1.jpg

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