Blatchley Iii Ernest R, Petri Brian, Sun Wenjun
Lyles School of Civil Engineering, Purdue University, West Lafayette, IN 47907, USA.
Environmental and Ecological Engineering, Purdue University, West Lafayette, IN 47907, USA.
J Res Natl Inst Stand Technol. 2021 Aug 20;126:126018. doi: 10.6028/jres.126.018. eCollection 2021.
Ultraviolet (UV) radiation in the wavelength range 200 nm ≤ λ ≤ 320 nm, which includes both the UV-C and UV-B portions of the spectrum, is known to be effective for inactivation of a wide range of microbial pathogens, including viruses. Previous research has indicated UV-C radiation to be effective for inactivation of severe acute respiratory syndrome coronavirus (SARS-CoV), the virus that caused an outbreak of SARS in 2003. Given the structural similarities of SARS-CoV and SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), it is anticipated that UV radiation should be effective for inactivation of SARS-CoV-2 too. Recently published data support this assertion, but only for a narrow set of exposure and matrix conditions. Models based on genomic and other characteristics of viruses have been developed to provide predictions of viral inactivation responses to UV exposure at λ = 254 nm. The predictions of these models are consistent with reported measurements of viral inactivation, including for SARS-CoV-2. As such, current information indicates that UV-C irradiation should be effective for control of SARS-CoV-2, as well as for control of other coronaviruses; however, additional research is needed to quantify the effects of several important process variables, including the wavelength of radiation, the effects of relative humidity on airborne and surface-associated viruses, and the effects of the medium of exposure.
波长范围在200纳米≤λ≤320纳米的紫外线（UV）辐射，包括光谱中的UV - C和UV - B部分，已知对灭活包括病毒在内的多种微生物病原体有效。先前的研究表明，UV - C辐射对灭活严重急性呼吸综合征冠状病毒（SARS-CoV）有效，该病毒在2003年引发了SARS疫情。鉴于导致2019冠状病毒病（COVID-19）的SARS-CoV-2与SARS-CoV在结构上的相似性，可以预期紫外线辐射对灭活SARS-CoV-2也应有效。最近发表的数据支持了这一论断，但仅适用于一组狭窄的暴露和基质条件。基于病毒基因组和其他特征开发的模型，用于预测病毒在λ = 254纳米的紫外线照射下的灭活反应。这些模型的预测结果与报道的病毒灭活测量结果一致，包括对SARS-CoV-2的测量。因此，目前的信息表明，UV - C照射对控制SARS-CoV-2以及其他冠状病毒应该是有效的；然而，需要进一步的研究来量化几个重要过程变量的影响，包括辐射波长、相对湿度对空气传播和表面相关病毒的影响以及暴露介质的影响。
