Früholz Iris, Meyer-Luehmann Melanie
Department of Neurology, Medical Center - University of Freiburg, Freiburg, Germany.
Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Front Cell Neurosci. 2024 Sep 18;18:1456253. doi: 10.3389/fncel.2024.1456253. eCollection 2024.
Microglia, the resident immune cells of the central nervous system, play a crucial role in regulating adult neurogenesis and contribute significantly to the pathogenesis of Alzheimer's disease (AD). Under physiological conditions, microglia support and modulate neurogenesis through the secretion of neurotrophic factors, phagocytosis of apoptotic cells, and synaptic pruning, thereby promoting the proliferation, differentiation, and survival of neural progenitor cells (NPCs). However, in AD, microglial function becomes dysregulated, leading to chronic neuroinflammation and impaired neurogenesis. This review explores the intricate interplay between microglia and adult neurogenesis in health and AD, synthesizing recent findings to provide a comprehensive overview of the current understanding of microglia-mediated regulation of adult neurogenesis. Furthermore, it highlights the potential of microglia-targeted therapies to modulate neurogenesis and offers insights into potential avenues for developing novel therapeutic interventions.
小胶质细胞作为中枢神经系统的常驻免疫细胞，在调节成体神经发生中起关键作用，并在阿尔茨海默病（AD）的发病机制中发挥重要作用。在生理条件下，小胶质细胞通过分泌神经营养因子、吞噬凋亡细胞和进行突触修剪来支持和调节神经发生，从而促进神经祖细胞（NPCs）的增殖、分化和存活。然而，在AD中，小胶质细胞的功能失调，导致慢性神经炎症和神经发生受损。本综述探讨了健康状态和AD中，小胶质细胞与成体神经发生之间复杂的相互作用，综合近期研究结果，全面概述了目前对小胶质细胞介导的成体神经发生调节的理解。此外，它强调了针对小胶质细胞的疗法调节神经发生的潜力，并为开发新型治疗干预措施的潜在途径提供了见解。
