Zhang Ziyi, Tang Runqun, Liu Xiaoyang, Liang Gaolin, Sun Xianbao
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 211189, China.
Handan Norman Technology Co., Ltd, Guantao, 057750, China.
Macromol Biosci. 2025 Feb;25(2):e2400409. doi: 10.1002/mabi.202400409. Epub 2024 Oct 3.
Self-assembling peptide-based materials with ordered nanostructures possess advantages such as good biocompatibility and biodegradability, superior controllability, and ease of chemical modification. Through covalent conjugation or non-covalent encapsulation, photosensitizers (PSs) can be carried by self-assembling peptide-based nanomaterials for targeted delivery towards tumor tissues. This improves the stability, solubility, and tumor accumulation of PSs, as well as reduces their dark toxicity. More importantly, these nanomaterials can be tailored with responsiveness to tumor microenvironment, which enables smart release of PSs for precise and enhanced photodynamic therapy (PDT). In this review, the self-assembly of peptide from the perspective of driving forces is first described, and various self-assembling peptide materials with zero to 3D nanostructures are subsequently highlighted for PDT of cancers in recent years. Finally, an outlook in this field is provided to motivate fabrication of advanced PDT nanomaterials.
具有有序纳米结构的基于自组装肽的材料具有生物相容性和生物降解性良好、可控性强以及易于化学修饰等优点。通过共价共轭或非共价封装，基于自组装肽的纳米材料可以携带光敏剂（PSs），实现向肿瘤组织的靶向递送。这提高了PSs的稳定性、溶解性和肿瘤蓄积性，同时降低了它们的暗毒性。更重要的是，这些纳米材料可以设计成对肿瘤微环境具有响应性，从而实现PSs的智能释放，以进行精确且增强的光动力疗法（PDT）。在本综述中，首先从驱动力的角度描述了肽的自组装，随后重点介绍了近年来用于癌症PDT的各种具有零维到三维纳米结构的自组装肽材料。最后，对该领域进行了展望，以推动先进PDT纳米材料的制备。
