College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan, 250014, P. R. China.
Chem Asian J. 2018 Nov 2;13(21):3122-3149. doi: 10.1002/asia.201801221. Epub 2018 Oct 12.
Photodynamic therapy (PDT) is a highly effective, noninvasive, highly selective method for cancer treatment. Nanoscale metal-organic frameworks (NMOFs) are a type of crystalline hybrid material composed of metal centers and organic linkers. Owing to their adjustable structure, easy modification, permanent pores, and good biocompatibility, NMOFs, as either nanophotosensitizers or photosensitizer nanocarriers, have been used in PDT. In this article, we summarize the recent progress in MOF-based nanomaterials for tumor PDT. The MOF-based nanomaterials might open up new avenues for the fabrication of new types of photosensitizers for PDT.
光动力疗法（PDT）是一种高效、非侵入性、高度选择性的癌症治疗方法。纳米级金属-有机框架（NMOFs）是一种由金属中心和有机配体组成的晶态杂化材料。由于其结构可调、易于修饰、永久孔隙和良好的生物相容性，NMOFs 作为纳米光敏剂或光敏剂纳米载体，已被用于光动力治疗。本文总结了基于 MOF 的纳米材料在肿瘤光动力治疗中的最新进展。基于 MOF 的纳米材料可能为 PDT 新型光敏剂的制备开辟新途径。
