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一种有用的参数规范,用于对流行病学数据进行建模:复活的 Richards 曲线。

A useful parametric specification to model epidemiological data: Revival of the Richards' curve.

机构信息

Department of Political Sciences, Roma Tre University, Rome, Italy.

Department GEPLI, LUMSA University, Rome, Lazio, Italy.

出版信息

Stat Methods Med Res. 2024 Aug;33(8):1473-1494. doi: 10.1177/09622802241262522.

Abstract

A useful parametric specification for the expected value of an epidemiological process is revived, and its statistical and empirical efficacy are explored. The Richards' curve is flexible enough to adapt to several growth phenomena, including recent epidemics and outbreaks. Here, two different estimation methods are described. The first, based on likelihood maximisation, is particularly useful when the outbreak is still ongoing and the main goal is to obtain sufficiently accurate estimates in negligible computational run-time. The second is fully Bayesian and allows for more ambitious modelling attempts such as the inclusion of spatial and temporal dependence, but it requires more data and computational resources. Regardless of the estimation approach, the Richards' specification properly characterises the main features of any growth process (e.g. growth rate, peak phase etc.), leading to a reasonable fit and providing good short- to medium-term predictions. To demonstrate such flexibility, we show different applications using publicly available data on recent epidemics where the data collection processes and transmission patterns are extremely heterogeneous, as well as benchmark datasets widely used in the literature as illustrative.

摘要

一种用于预测流行病学过程的有用参数规范被重新提出,并对其统计和经验效果进行了探索。Richards 曲线非常灵活,可以适应多种增长现象,包括最近的传染病爆发。在这里,描述了两种不同的估计方法。第一种方法基于似然最大化,当爆发仍在继续且主要目标是在可忽略的计算运行时间内获得足够准确的估计时,这种方法特别有用。第二种方法是完全贝叶斯的,允许进行更具雄心的建模尝试,例如包括空间和时间依赖性,但它需要更多的数据和计算资源。无论采用哪种估计方法,Richards 规范都能很好地描述任何增长过程的主要特征(例如增长率、峰值阶段等),从而实现合理的拟合,并提供良好的短期到中期预测。为了展示这种灵活性,我们使用最近传染病爆发的公开可用数据以及文献中广泛用作示例的基准数据集展示了不同的应用。

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