Coler Brahm, Honerkamp Smith Gordon, Arora Anish K, Wells Adam, Solso Stephanie, Dullano Cheryl, Concha-Garcia Susanna, Hill Eddie, Riggs Patricia K, Korolkova Anastasia, Deiss Robert, Smith Davey, Sundermann Erin E, Gianella Sara, Chaillon Antoine, Dubé Karine
School of Medicine, University of Washington, Seattle, WA.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA.
J Acquir Immune Defic Syndr. 2025 Jan 1;98(1):82-89. doi: 10.1097/QAI.0000000000003536. Epub 2024 Dec 5.
As people living with HIV (PWH) age, they face new challenges that can have a negative impact on their quality of life (QOL) and mental health.
This study enrolled PWH at the end of life (EOL) who were actively engaged in cure-related research in Southern California, United States. EOL was defined as having a prognosis of 6 months or less to live. We examined the relationship between QOL, mental health, and research participation.
Structured assessments were used to collect comprehensive data on QOL and mental health.
From 2017 to 2023, 35 PWH in their final stages of life who were actively engaged in cure-related research were enrolled. Their median age was 62.7 years, and most were White or otherwise non-Hispanic/non-Latino (90.6%), and male (86.7%). Changes in QOL and the presence of neurologic and psychiatric conditions, with a focus on depression and anxiety, were the primary outcomes assessed in this study. Participants had stable QOL scores throughout the study. There was an inverse relationship between QOL and Beck Depression Inventory scores, with higher mean QOL scores being associated with lower mean Beck Depression Inventory scores ( P < 0.001).
QOL remained stable among PWH who participate in cure-related research at EOL. The inverse relationship between QOL and depressive symptoms suggests that participation in cure-related research may improve QOL or reduce depressive symptoms in this population. Future interventions should look into ways to improve the well-being of PWH at EOL through research and customized mental health interventions.
随着感染艾滋病毒者（PWH）年龄增长，他们面临着可能对其生活质量（QOL）和心理健康产生负面影响的新挑战。
本研究纳入了美国南加州积极参与治愈相关研究的临终（EOL）艾滋病毒感染者。临终被定义为预后存活时间为6个月或更短。我们研究了生活质量、心理健康与研究参与之间的关系。
采用结构化评估收集有关生活质量和心理健康的综合数据。
2017年至2023年，纳入了35名处于生命最后阶段且积极参与治愈相关研究的艾滋病毒感染者。他们的中位年龄为62.7岁，大多数为白人或其他非西班牙裔/非拉丁裔（90.6%），男性（86.7%）。生活质量的变化以及神经和精神疾病的存在，重点是抑郁和焦虑，是本研究评估的主要结果。在整个研究过程中，参与者的生活质量得分保持稳定。生活质量与贝克抑郁量表得分呈负相关，平均生活质量得分越高，贝克抑郁量表平均得分越低（P<0.001）。
参与临终治愈相关研究的艾滋病毒感染者的生活质量保持稳定。生活质量与抑郁症状之间的负相关表明，参与治愈相关研究可能会改善该人群的生活质量或减轻抑郁症状。未来的干预措施应研究如何通过研究和定制的心理健康干预来改善临终艾滋病毒感染者的福祉。
