Swansea University Medical School, Swansea University, Swansea, UK.
Edinburgh Clinical Trials Unit, Usher Institute, The University of Edinburgh, Edinburgh, UK.
Seizure. 2024 Nov;122:52-57. doi: 10.1016/j.seizure.2024.09.008. Epub 2024 Sep 11.
Information on self-limited epilepsy with centrotemporal spikes (SeLECTS) epidemiology is limited. We aimed to determine the incidence of SeLECTS in children, its association with socioeconomic deprivation and the prevalence of neurodevelopmental comorbidities.
We performed a retrospective cohort study (2004-2017) using anonymised, linked, routinely collected, primary care and demographic data for children in Wales. We used primary care diagnosis codes to identify children (aged 0-16 years) with SeLECTS and other epilepsies and to record antiseizure medication (ASM) prescriptions and neurodevelopmental comorbidities. We used a mixed effects Poisson regression model to determine temporal trends of SeLECTS incidence and its association with socioeconomic deprivation.
We identified 6,732 children with epilepsy, 186 (3%) with SeLECTS. In 2017, epilepsy and SeLECTS prevalence was 0.55% and 0.02% respectively with corresponding crude incidence of 51.2/100,000/year and 1.1/100,000/year. The incidence of epilepsy in children decreased with decreasing deprivation with an adjusted incidence rate ratio (AIRR) of 0.72 (95% CI 0.64-0.82) in the least deprived compared with the most deprived quintile. The corresponding AIRR for children with SeLECTS was 1.35 (95% CI 0.46-1.99). 34% of children with epilepsy, 18% of children with SeLECTS and 3% of all children in Wales had a neurodevelopmental disorder and or school problems. Half of children with SeLECTS were treated with ASM.
We identified a lower than previously reported incidence of SeLECTS, which may be due to under-recording of SeLECTS. There was no change in the incidence of SeLECTS over time, whilst the incidence of childhood epilepsy overall was decreasing. There was no significant association between incidence of SeLECTS and deprivation but the modest sample size needs to be considered. Children with SeLECTS should be screened for neurodevelopmental and or learning comorbidities. Treatment for SeLECTS remains debatable.
关于良性部分性癫痫伴中央颞区棘波（BECTS）的流行病学信息有限。我们旨在确定儿童 BECTS 的发病率，及其与社会经济剥夺的关系，以及神经发育合并症的患病率。
我们进行了一项回顾性队列研究（2004-2017 年），使用威尔士儿童的匿名、链接、常规收集的初级保健和人口统计学数据。我们使用初级保健诊断代码来识别患有 BECTS 和其他癫痫的儿童，并记录抗癫痫药物（ASM）处方和神经发育合并症。我们使用混合效应泊松回归模型来确定 BECTS 发病率的时间趋势及其与社会经济剥夺的关系。
我们确定了 6732 名患有癫痫的儿童，其中 186 名（3%）患有 BECTS。2017 年，癫痫和 BECTS 的患病率分别为 0.55%和 0.02%，相应的粗发病率为 51.2/100000/年和 1.1/100000/年。儿童癫痫的发病率随剥夺程度的降低而降低，与最贫困五分位数相比，最不贫困五分位数的调整发病率比（AIRR）为 0.72（95%CI 0.64-0.82）。BECTS 儿童的相应 AIRR 为 1.35（95%CI 0.46-1.99）。34%的癫痫儿童、18%的 BECTS 儿童和威尔士所有儿童的 3%患有神经发育障碍和/或学业问题。一半的 BECTS 儿童接受了 ASM 治疗。
我们发现 BECTS 的发病率低于之前报道的水平，这可能是由于 BECTS 的记录不足。随着时间的推移，BECTS 的发病率没有变化，而儿童癫痫的总体发病率在下降。BECTS 的发病率与剥夺之间没有显著关联，但需要考虑到样本量较小。BECTS 儿童应进行神经发育和/或学习合并症的筛查。BECTS 的治疗仍存在争议。
