Mihatsch M J, Torhorst J, Steinmann E, Hofer H, Stickelberger M, Bianchi L, Berneis K, Zollinger H U
Pathol Res Pract. 1979 Apr;164(1):68-79. doi: 10.1016/S0344-0338(79)80094-1.
A number of different morphologic characteristics were examined to determine their relative values in establishing a purely morphologic diagnosis of phenacetin abuse. These included hyperpigmentation of the skin, the costal cartilages, the liver, and the renal tubules, and capillarosclerosis of the lower urinary tract. Hyperpigmentation of the skin, liver, and renal tubules cannot be used in the diagnosis of phenacetin abuse. Massive brown pigmentation of the costal cartilages in patients under 60 years of age suggests phenacetin abuse, but even this morphologic parameter, when used alone, is insufficient to establish a definite diagnosis. Capillarosclerosis in the lower urinary tract does, however, permit one to diagnose phenacetin abuse with certainty, as it is found exclusively in this condition.
为确定在建立非那西丁滥用的纯形态学诊断中各种不同形态学特征的相对价值，对其进行了多项检查。这些特征包括皮肤、肋软骨、肝脏和肾小管的色素沉着，以及下尿路的毛细血管硬化。皮肤、肝脏和肾小管的色素沉着不能用于非那西丁滥用的诊断。60岁以下患者肋软骨大量棕色色素沉着提示非那西丁滥用，但即使是这一形态学参数单独使用时也不足以确诊。然而，下尿路的毛细血管硬化确实能让人明确诊断非那西丁滥用，因为它仅见于这种情况。
