Dieussaert Emiel, Baets Roel, Jans Hilde, Rottenberg Xavier, Li Yanlu
Photonics Research Group, Ghent University-IMEC, Technologiepark-Zwijnaarde 126, 9052, Ghent, Belgium.
Center for Nano- and Biophotonics, Ghent University, Technologiepark-Zwijnaarde 126, 9052, Ghent, Belgium.
Sci Rep. 2024 Oct 3;14(1):22953. doi: 10.1038/s41598-024-74266-y.
Photoacoustic imaging has emerged as a powerful, non-invasive modality for various biomedical applications. Conventional photoacoustic systems require contact-based ultrasound detection and expensive, bulky high-power lasers for the excitation. The use of contact-based detectors involves the risk of contamination, which is undesirable for most biomedical applications. While other non-contact detection methods can be bulky, in this paper, we demonstrate a proof-of-concept experiment for compact and contactless detection of photoacoustic signals on silicone samples embedded with ink-filled channels. A silicon photonics-based Laser Doppler Vibrometer (LDV) detects the acoustic waves excited by a compact pulsed laser diode. By scanning the LDV beam over the surface of the sample, 2D photoacoustic images were reconstructed of the sample.
光声成像已成为一种用于各种生物医学应用的强大的非侵入性成像方式。传统的光声系统需要基于接触的超声检测以及用于激发的昂贵、笨重的高功率激光器。使用基于接触的探测器存在污染风险，这对于大多数生物医学应用来说是不可取的。虽然其他非接触检测方法可能体积庞大，但在本文中，我们展示了一个概念验证实验，用于对嵌入充满墨水通道的硅树脂样品进行光声信号的紧凑且非接触式检测。一种基于硅光子学的激光多普勒振动计（LDV）检测由紧凑脉冲激光二极管激发的声波。通过在样品表面扫描LDV光束，重建了样品的二维光声图像。
