一种采用激光二极管激发的低成本光声显微镜系统。
A low-cost photoacoustic microscopy system with a laser diode excitation.
作者信息
Wang Tianheng, Nandy Sreyankar, Salehi Hassan S, Kumavor Patrick D, Zhu Quing
机构信息
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT 06269, USA.
Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
出版信息
Biomed Opt Express. 2014 Aug 14;5(9):3053-8. doi: 10.1364/BOE.5.003053. eCollection 2014 Sep 1.
Abstract
Photoacoustic microscopy (PAM) is capable of mapping microvasculature networks in biological tissue and has demonstrated great potential for biomedical applications. However, the clinical application of the PAM system is limited due to the use of bulky and expensive pulsed laser sources. In this paper, a low-cost optical-resolution PAM system with a pulsed laser diode excitation has been introduced. The lateral resolution of this PAM system was estimated to be 7 µm by imaging a carbon fiber. The phantoms made of polyethylene tubes filled with blood and a mouse ear were imaged to demonstrate the feasibility of this PAM system for imaging biological tissues.
摘要
光声显微镜（PAM）能够绘制生物组织中的微血管网络，并已在生物医学应用中展现出巨大潜力。然而，由于使用体积庞大且昂贵的脉冲激光源，PAM系统的临床应用受到限制。本文介绍了一种采用脉冲激光二极管激发的低成本光学分辨率PAM系统。通过对碳纤维成像，估计该PAM系统的横向分辨率为7微米。对由充满血液的聚乙烯管制成的体模和小鼠耳朵进行成像，以证明该PAM系统用于生物组织成像的可行性。
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