Docherty Sarah, Wetherell Mark A, McInnes Lynn, Haskell-Ramsay Crystal F
Department of Psychology, Northumbria University, Newcastle upon Tyne, UK.
Eur J Clin Nutr. 2025 Mar;79(2):126-135. doi: 10.1038/s41430-024-01517-6. Epub 2024 Oct 3.
Research has indicated the potential for multivitamin-mineral (MVM) supplementation to improve aspects of wellbeing and cognitive function in older adults via a range of biological mechanisms. However, outside of cognitive function and mood, this research rarely assesses other outcomes that are pertinent to the daily lives of older adults. The current study aimed to investigate the effectiveness of a MVM supplement on meaningful outcomes of everyday functioning in older adults.
This randomised, double-blind, placebo-controlled, parallel groups trial investigated the effects of 12-week MVM supplementation on measures of wellbeing, mood, and memory; physical health and activity; and social interaction and loneliness. Outcomes were measured at baseline and after 12 weeks in a sample of 228 (124 female) older adults ( > 70 years).
MVM supplementation had no effect on the primary outcome of wellbeing (p = 0.29 in males, p = 0.421 in females), but led to increased feelings of friendliness in females (p = 0.045). In males, following MVM, there were lower levels of prolonged stress reactivity (p = 0.007), lower overall stress reactivity (p = 0.019), and lower emotional loneliness (p = 0.042).
This study provides novel evidence of increased friendliness and decreased stress reactivity and loneliness following MVM supplementation in older adults. These findings support the exploration of broader functions pertinent to aspects of daily living in older adults. Sex differences in response highlight the importance of exploring effects in men and women separately and support a recommendation for the inclusion of diverse samples in future research that are representative of the population.
研究表明，通过一系列生物学机制，补充多种维生素和矿物质（MVM）有可能改善老年人的幸福感和认知功能。然而，除了认知功能和情绪外，这项研究很少评估与老年人日常生活相关的其他结果。本研究旨在调查MVM补充剂对老年人日常功能有意义结果的有效性。
这项随机、双盲、安慰剂对照、平行组试验研究了12周MVM补充剂对幸福感、情绪和记忆；身体健康和活动；以及社交互动和孤独感的影响。在228名（124名女性）70岁以上老年人的样本中，在基线和12周后测量结果。
补充MVM对幸福感的主要结果没有影响（男性p = 0.29，女性p = 0.421），但导致女性的友好感增加（p = 0.045）。在男性中，补充MVM后，长期应激反应水平较低（p = 0.007），总体应激反应较低（p = 0.019），情绪孤独感较低（p = 0.042）。
本研究提供了新的证据，表明老年人补充MVM后友好感增加，应激反应和孤独感降低。这些发现支持探索与老年人日常生活相关的更广泛功能。反应中的性别差异突出了分别研究男性和女性影响的重要性，并支持在未来研究中纳入具有代表性的多样化样本的建议。
