Gorun Florin, Motoi Sorin, Malita Daniel, Navolan Dan Bogdan, Nemescu Dragos, Olariu Tudor Rares, Craina Marius, Vilibic-Cavlek Tatjana, Ciohat Ioana, Boda Daniel, Dobrescu Amadeus
Department of Obstetrics and Gynecology, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Department of Medical Imaging and Radiology, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Exp Ther Med. 2020 Sep;20(3):2439-2443. doi: 10.3892/etm.2020.8945. Epub 2020 Jun 25.
Cytomegalovirus (CMV) infection is the most common congenital infection worldwide, and remains a significant cause of the neurological deficiency and sensory deafness in developed countries. Maternal primary infection, reactivation or reinfection during pregnancy may lead to fetal infection and congenital CMV syndrome. The purpose of this study was to analyze the CMV seroprevalence according to demographic features of pregnant women in western Romania as well as the evolution of CMV immunity in two time intervals. IgG anti-CMV antibodies were tested in sera of 8,951 pregnant women during two successive intervals: 2008-2010 (n=1466) and 2015-2018 (n=7485). The CMV seroprevalence in women of reproductive age decreased from 94.6 to 91.80% in the last decade. The seroprevalence was higher in women from rural areas compared with those from urban areas. These results show that the western region of Romania has a low-risk profile for primary CMV infection during pregnancy due to a large number of seropositive women. However, this risk has increased in the last ten years, from 5.4 to 8.2%, which may show the need to implement a national screening program.
巨细胞病毒（CMV）感染是全球最常见的先天性感染，在发达国家仍是导致神经功能缺陷和感音神经性耳聋的重要原因。孕期母体原发性感染、病毒再激活或再次感染可能导致胎儿感染及先天性CMV综合征。本研究旨在根据罗马尼亚西部孕妇的人口统计学特征分析CMV血清流行率，以及两个时间段内CMV免疫情况的演变。在两个连续时间段（2008 - 2010年，n = 1466；2015 - 2018年，n = 7485）对8951名孕妇的血清进行了IgG抗CMV抗体检测。过去十年中，育龄女性的CMV血清流行率从94.6%降至91.80%。农村地区女性的血清流行率高于城市地区女性。这些结果表明，由于大量血清学阳性女性的存在，罗马尼亚西部地区孕期原发性CMV感染风险较低。然而，在过去十年中，这一风险已从5.4%升至8.2%，这可能表明需要实施全国性筛查计划。
