vSPACE：探索关节软骨细胞在单细胞水平的虚拟空间表示。
vSPACE: exploring virtual spatial representation of articular chondrocytes at the single-cell level.
机构信息
School of Computing, University of Connecticut, Storrs, CT 06269-4155, United States.
Departments of Molecular and Cell Biology and Molecular Medicine, Scripps Research, La Jolla, CA 92037, United States.
出版信息
Bioinformatics. 2024 Oct 1;40(10). doi: 10.1093/bioinformatics/btae568.
SUMMARY
vSPACE is a web-based application presenting a spatial representation of scRNAseq data obtained from human articular cartilage by emulating the concept of spatial transcriptomics technology, but virtually. This virtual 2D plot presentation of human articular cartage cells generates several zonal distribution patterns, for one or multiple genes at a time, revealing patterns that scientists can appreciate as imputed spatial distribution patterns along the zonal axis.
AVAILABILITY AND IMPLEMENTATION
vSPACE is implemented in Python Dash as a web-based toolbox designed for data visualization of zonal gene expression patterns in articular cartilage chondrocytes. This tool is freely accessible at: https://vspace.cse.uconn.edu/The source code and extra materials for this service can be downloaded from: https://github.com/zhacheny/vSPACE.
摘要
vSPACE 是一个基于网络的应用程序，通过模拟空间转录组学技术的概念，但实际上是虚拟的，来呈现从人关节软骨中获得的 scRNAseq 数据的空间表示。这种虚拟的 2D 人关节软骨细胞图谱展示生成了多个区域分布模式，一次可显示一个或多个基因的模式，揭示了科学家可以理解的沿区域轴推测的空间分布模式。
可用性和实现
vSPACE 是使用 Python Dash 实现的，是一个基于网络的工具包，用于可视化关节软骨细胞中区域基因表达模式。该工具可在以下网址免费获得：https://vspace.cse.uconn.edu/。此服务的源代码和其他材料可从以下网址下载：https://github.com/zhacheny/vSPACE。
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