Tinawi Mohammad
Nephrology, Nephrology Specialists, Munster, USA.
Cureus. 2024 Sep 3;16(9):e68543. doi: 10.7759/cureus.68543. eCollection 2024 Sep.
Eduardo Alberto Slatopolsky (1934-2024), Washington University Joseph Friedman Professor Emeritus of Medicine, a prominent physician-scientist, was born in Buenos Aires, Argentina. The impact of his research in the area of mineral and bone disorders in kidney disease has been profound for over 50 years starting in the 1960s. He was a global authority on secondary hyperparathyroidism. He was instrumental in illustrating the role of hyperphosphatemia in chronic kidney disease (CKD) and in developing the first reliable parathyroid hormone (PTH) assay. His research led to the utilization of calcium salts as phosphate binders replacing the toxic aluminum salts. Moreover, he illustrated the role of vascular calcifications in CKD patients, paving the way for non-calcium phosphate binders. He proposed the use of calcitriol and later vitamin D analogs in the management of secondary hyperparathyroidism, which is the current standard of care. He demonstrated the decreased expression of the calcium-sensing receptor in parathyroid tissue in CKD patients. Dr. Slatopolsky's global legacy will last for generations.
爱德华多·阿尔韦托·斯拉托波尔斯基（1934 - 2024），华盛顿大学约瑟夫·弗里德曼医学荣誉退休教授，杰出的医学科学家，出生于阿根廷布宜诺斯艾利斯。从20世纪60年代开始，他在肾脏疾病的矿物质和骨骼疾病领域的研究影响深远，长达50多年。他是继发性甲状旁腺功能亢进症的全球权威。他在阐明高磷血症在慢性肾脏病（CKD）中的作用以及开发首个可靠的甲状旁腺激素（PTH）检测方法方面发挥了重要作用。他的研究促使使用钙盐作为磷结合剂，取代了有毒的铝盐。此外，他阐明了血管钙化在CKD患者中的作用，为非钙磷结合剂的应用铺平了道路。他提出使用骨化三醇及后来的维生素D类似物来治疗继发性甲状旁腺功能亢进症，这是目前的标准治疗方法。他证明了CKD患者甲状旁腺组织中钙敏感受体的表达降低。斯拉托波尔斯基博士的全球遗产将延续几代人。
