Tian Dan, Teng Chong, Lv Yanju, Duan Xiaozhuo, Wang Yi, Song Xiaowei, Jiang Qiuying, Huang Dayong, Xin Tao, Yang Yu, Li Li
Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Discov Oncol. 2024 Oct 4;15(1):522. doi: 10.1007/s12672-024-01342-0.
Cutaneous squamous cell carcinoma (CSCC) is common among the elderly, typically treated with surgery. However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with recurrent back CSCC and intractable malignant ulcers post-radiotherapy and chemotherapy. Treatment involved Hematoporphyrin Derivative (HpD) Photodynamic Therapy (PDT) with low-dose cindilimab immunotherapy (intravenous and intralesional). Two cycles achieved lesion remission, altering peripheral immune cell counts. HpD-PDT combined with immunotherapy is promising for treating CSCC, particularly with malignant ulcers.
皮肤鳞状细胞癌（CSCC）在老年人中很常见，通常采用手术治疗。然而，对于不适合手术的患者或伤口不愈合并发展为恶性溃疡的患者，非手术局部治疗是可行的。本病例详细介绍了一名80岁的复发性背部CSCC患者，在放疗和化疗后出现顽固性恶性溃疡。治疗采用血卟啉衍生物（HpD）光动力疗法（PDT）联合低剂量信迪利单抗免疫疗法（静脉注射和瘤内注射）。两个周期后病变缓解，外周免疫细胞计数发生改变。HpD-PDT联合免疫疗法在治疗CSCC方面具有前景，尤其是对于伴有恶性溃疡的患者。
