Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2G6, Canada.
Materials Science and Engineering Program, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Langmuir. 2024 Oct 15;40(41):21795-21803. doi: 10.1021/acs.langmuir.4c02984. Epub 2024 Oct 4.
Gold nanorods (GNRs) are unique nanoparticles with easily functionalized surfaces, multiple synthesis methods, photothermal conversion, and surface plasmon resonance effects. These properties make GNRs suitable for various biological applications. However, a rapid synthesis of GNRs using less toxic chemicals is needed. The photochemical method is a viable option that can synthesize GNRs quickly while using fewer chemicals. A photochemical method is reported for the synthesis of GNRs using Irgacure-2959 as a reducing agent. This method could be used to synthesize GNRs with a rod-like shape within 30 min. Additionally, GNRs were coated with sericin (GNRs-SC) to further reduce their toxicity in human dermal fibroblast adult cells. Low-level near-infrared (NIR) light was applied to enhance the photothermal therapy of both GNRs and GNRs-SC. The results showed that GNRs and GNRs-SC under low-level NIR light have enhanced antibacterial activity against and , as well as antibiofilm activity against . Furthermore, GNRs-SC showed good biocompatibility with antibacterial and antibiofilm activities. These results indicate that GNRs-SC are good candidates for various biological applications.
金纳米棒（GNRs）是具有易功能化表面、多种合成方法、光热转换和表面等离激元共振效应的独特纳米粒子。这些特性使 GNRs 适用于各种生物应用。然而，需要使用毒性较小的化学物质快速合成 GNRs。光化学方法是一种可行的选择，它可以在使用较少化学物质的情况下快速合成 GNRs。本文报道了一种使用 Irgacure-2959 作为还原剂合成 GNRs 的光化学方法。该方法可以在 30 分钟内合成出具有棒状形状的 GNRs。此外，将丝胶（GNRs-SC）涂覆在 GNRs 表面以进一步降低其在人真皮成纤维细胞中的毒性。应用低强度近红外（NIR）光来增强 GNRs 和 GNRs-SC 的光热治疗效果。结果表明，在低强度 NIR 光下的 GNRs 和 GNRs-SC 对 和 具有增强的抗菌活性，对 具有增强的抗生物膜活性。此外，GNRs-SC 表现出良好的生物相容性和抗菌、抗生物膜活性。这些结果表明 GNRs-SC 是各种生物应用的良好候选物。
