普遍存在的泛素：从细菌到真核生物。

Ubiquitous ubiquitin: From bacteria to eukaryotes.

机构信息

Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue Straße 15, 60438 Frankfurt am Main, Germany; Fraunhofer Institute of Translational Medicine and Pharmacology, Carl-von-Noorden-Platz 9, 60596 Frankfurt am Main, Germany.

出版信息

Structure. 2024 Oct 3;32(10):1552-1554. doi: 10.1016/j.str.2024.09.002.

DOI:10.1016/j.str.2024.09.002

PMID:39366338

Abstract

In a recent issue of Nature, Chambers et al. combined bioinformatics, biochemistry, and X-ray crystallography to uncover the presence of a ubiquitin-like machinery in bacteria, which was believed to be unique to archaea and eukaryotes. This study highlights the prevalence of a ubiquitin-like system in bacteria that was later adopted by the eukaryotes for various purposes such as protein degradation.

摘要

在最近的一期《自然》杂志上，钱伯斯等人结合生物信息学、生物化学和 X 射线晶体学，揭示了细菌中存在一种泛素样机制，这种机制被认为是古菌和真核生物所特有的。这项研究强调了泛素样系统在细菌中的普遍性，后来真核生物也采用了这种系统来实现各种目的，如蛋白质降解。