长期服用炔诺酮对恒河猴垂体促性腺激素活性的影响。
Effect of prolonged centchroman treatment on pituitary gonadotrophic activity in rhesus monkeys.
作者信息
Singh M M, Kamboj V P
机构信息
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
出版信息
Indian J Exp Biol. 1991 Dec;29(12):1145-6.
PMID:1816103
Abstract
Daily oral administration of antiestrogen centchroman at 6.25, 12.5 and 25 mg/kg doses to adult female rhesus monkeys continuously for one year caused no significant effect on their total pituitary gonadotrophin content as evidenced by an almost similar extent of uterine weight gain, premature opening of vagina and cornification of vaginal epithelium in immature female mice treated with pituitary homogenates from control and centchroman treated monkeys.
摘要
对成年雌性恒河猴每日口服6.25、12.5和25毫克/千克剂量的抗雌激素色满卡林，持续一年，对其垂体促性腺激素总量没有显著影响，这一点可通过以下现象得到证明：用来自对照猴和色满卡林处理猴的垂体匀浆处理的未成熟雌性小鼠，其子宫重量增加、阴道过早开放和阴道上皮角质化的程度几乎相似。
相似文献
1
Effect of prolonged centchroman treatment on pituitary gonadotrophic activity in rhesus monkeys.长期服用炔诺酮对恒河猴垂体促性腺激素活性的影响。
Indian J Exp Biol. 1991 Dec;29(12):1145-6.
2
Effect of long-term centchroman treatment on plasma steroid and peptide hormones in female rhesus monkeys (Macaca mulatta).长期服用左旋炔诺孕酮对雌性恒河猴（猕猴）血浆甾体和肽类激素的影响。
Contraception. 1985 Sep;32(3):283-99. doi: 10.1016/0010-7824(85)90052-6.
3
Mode of action of centchroman at vaginal and ovarian level in immature rats.炔诺酮在未成熟大鼠阴道和卵巢水平的作用模式。
Indian J Physiol Pharmacol. 1980 Jan-Mar;24(1):43-8.
4
Carbohydrate metabolism in the genital organs of adult female rhesus monkeys: effect of prolonged treatment with centchroman, an antiimplantation agent.成年雌性恒河猴生殖器官中的碳水化合物代谢：抗着床剂炔诺酮长期治疗的影响
Exp Clin Endocrinol. 1985 Dec;86(3):266-72. doi: 10.1055/s-0029-1210496.
5
Monoamine oxidase activity in the pituitary of mice after estrogen, progesterone and centchroman treatment.雌激素、孕酮和醋炔诺酮处理后小鼠垂体中的单胺氧化酶活性
Indian J Physiol Pharmacol. 1978 Jul-Sep;22(3):310-2.
6
Effect of centchroman and tamoxifen on protein patterns of fallopian tubes of rhesus monkeys, Macaca mulatta.醋酸棉酚和他莫昔芬对恒河猴（猕猴）输卵管蛋白质模式的影响。
Indian J Exp Biol. 1992 Oct;30(10):913-4.
7
Monoamine oxidase concentration in median eminence, pituitary and uterus of rat after estrogen and centchroman treatment.雌激素和醋炔诺酮治疗后大鼠正中隆起、垂体和子宫中单胺氧化酶的浓度
Indian J Physiol Pharmacol. 1981 Jan-Mar;25(1):80-2.
8
Effect of Centchroman on serum gonadotropins & prolactin in rats.双醋炔诺醇对大鼠血清促性腺激素及催乳素的影响。
Indian J Exp Biol. 1977 Dec;15(12):1191-3.
9
Centchroman--elicited depletion of cyclic AMP in incubated rat hypothalami.己烯雌酚诱发孵育大鼠下丘脑环磷酸腺苷耗竭。
Indian J Exp Biol. 1978 Apr;16(4):493-5.
10
Effect of L-dopa on Centchroman induced prolactin levels in female rats.左旋多巴对己烷雌酚诱导的雌性大鼠催乳素水平的影响。
Indian J Exp Biol. 1977 Dec;15(12):1193-4.
Zotero 插件