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基于计算流体动力学的颅内动脉瘤支架诱导变形的研究。

Investigation of the stent induced deformation on hemodynamic of internal carotid aneurysms by computational fluid dynamics.

机构信息

Mathematics Area, MathLab, International School for Advanced Studies (SISSA), Trieste, Italy.

Department of Civil Engineering, College of Engineering, Cihan University-Erbil, Erbīl, Iraq.

出版信息

Sci Rep. 2023 May 2;13(1):7155. doi: 10.1038/s41598-023-34383-6.

DOI:10.1038/s41598-023-34383-6
PMID:37130902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10154420/
Abstract

Application of the stent for treatment of the internal carotid artery (ICA) aneurysms has been extensively increased in recent decades. In the present work, stent-induced deformations of the parent vessel of ICA aneurysms are fully investigated. This study tries to visualize blood stream and calculated hemodynamic factors inside the four ICA aneurysms after deformations of parent vessel. For the simulation of the non-Newtonian blood stream, computational fluid dynamic is applied with one-way Fluid-Solid interaction (FSI) approach. Four ICA aneurysms with different ostium sizes and neck vessel angle are selected for this investigation. Wall shear stress on wall of aneurysm is analyzed in two angles of deformation due to application of the stent. Blood flow investigation shows that the deformation of the aneurysm limited blood entrance to the sac region and this decreases the blood velocity and consequently oscillatory shear index (OSI) on the sac wall. It is also observed that the stent-induced deformation is more effective on those cases with extraordinary OSI values on aneurysm wall.

摘要

近几十年来，支架在治疗颈内动脉（ICA）动脉瘤中的应用已经广泛增加。在本工作中，充分研究了支架引起的ICA 动脉瘤母体血管的变形。本研究试图在母体血管变形后可视化四个 ICA 动脉瘤内的血流和计算的血液动力学因素。为了模拟非牛顿血流，应用计算流体动力学并采用单向流固相互作用（FSI）方法。选择四个具有不同口部大小和颈部血管角度的 ICA 动脉瘤进行此项研究。由于支架的应用，分析了在两个变形角度下动脉瘤壁上的壁面剪切应力。血流研究表明，动脉瘤的变形限制了血液进入囊区的入口，从而降低了血流速度，进而降低了囊壁上的振荡剪切指数（OSI）。还观察到，支架引起的变形对那些动脉瘤壁上 OSI 值异常的病例更有效。

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