Kimby E, Mellstedt H, Björkholm M, Holm G
Hematol Oncol. 1985 Oct-Dec;3(4):261-9. doi: 10.1002/hon.2900030405.
The surface membrane immunoglobulin (smIg) isotype pattern of the leukemic lymphocytes was studied in 66 unselected patients with CLL. Five distinct patient groups were identified according to the dominant heavy chain isotype(s); I: smmu + (n = 22), II: smmu +/smdelta + (n = 25), III: smdelta + (n = 4), IV: smgamma + (n = 5), V: no detectable heavy chains (n = 10). The majority of group I patients had a progressive disease at test while all patients in group II were in a non-progressive state. Moreover, the smIg pattern changed with the clinical activity of the disease: when the disease progressed, the relative number of smmu + cells increased and when patients entered an indolent stage after treatment the smmu + cell population decreased. In patients with stationary disease the smIg pattern remained essentially unchanged or the relative number of smdelta + cells increased. These observations might suggest that the smIg isotype pattern of the leukemic cell population reflects the biological behaviour and the clinical activity of the disease.
对66例未经挑选的慢性淋巴细胞白血病（CLL）患者的白血病淋巴细胞表面膜免疫球蛋白（smIg）同种型模式进行了研究。根据主要重链同种型将患者分为五个不同的组：I组：smmu +（n = 22），II组：smmu +/smdelta +（n = 25），III组：smdelta +（n = 4），IV组：smgamma +（n = 5），V组：未检测到重链（n = 10）。I组的大多数患者在检测时病情呈进行性发展，而II组的所有患者均处于非进行性状态。此外，smIg模式随疾病的临床活动而变化：当疾病进展时，smmu +细胞的相对数量增加，而当患者在治疗后进入惰性阶段时，smmu +细胞群体减少。在病情稳定的患者中，smIg模式基本保持不变或smdelta +细胞的相对数量增加。这些观察结果可能表明白血病细胞群体的smIg同种型模式反映了疾病的生物学行为和临床活动。
