Berntorp E, Zettervall O
Scand J Haematol. 1985 Mar;34(3):213-8. doi: 10.1111/j.1600-0609.1985.tb02779.x.
Lymphocytes from 27 patients with B-type chronic lymphocytic leukaemia (CLL) were tested with immunofluorescence for expression of surface membrane immunoglobulin (SmIg) and the B cell antigen 7420. When age at time of testing, sex, clinical stage according to Binet, disease progression according to Levin and percentage of SmIg and 7420 antigen-expressing cells were used as explanatory variables for survival in a linear logistic regression model, only the SmIg variable was significant (p less than 0.025). A high proportion of SmIg bearing cells (greater than 61%) was associated with short survival, large tumour mass and aggressive disease. The tentative conclusion is drawn that the differentiation stage of the tumour cells in CLL determines the clinical course of the disease and is inversely correlated to the SmIg expression.
采用免疫荧光法检测了27例B型慢性淋巴细胞白血病（CLL）患者淋巴细胞的表面膜免疫球蛋白（SmIg）和B细胞抗原7420的表达。在一个线性逻辑回归模型中，将检测时的年龄、性别、根据比内（Binet）标准的临床分期、根据莱文（Levin）标准的疾病进展以及SmIg和7420抗原表达细胞的百分比作为生存的解释变量，结果只有SmIg变量具有显著性（p小于0.025）。高比例的携带SmIg的细胞（大于61%）与生存期短、肿瘤块大以及侵袭性疾病相关。初步得出结论，CLL中肿瘤细胞的分化阶段决定了疾病的临床进程，且与SmIg表达呈负相关。
