Bohus R, Waltzer W C, Frischer Z, Gonder M
Int Urol Nephrol. 1985;17(3):255-9. doi: 10.1007/BF02085412.
The complications of bleeding in patients with Waldenström's macroglobulinaemia (WM) are relatively well described. The pathophysiology of such a haemorrhagic diathesis is complex and involves the inhibition and depression of coagulation factors as well as qualitative and quantitative platelet abnormalities. Treatment of WM must be targeted at the underlying lymphocellular malignancy, but amelioration of the hyperviscous state and component transfusion(s) to correct abnormal coagulation parameters will decrease the incidence of bleeding. A case of WM with E. coli urinary tract infection and subsequent retroperitoneal haemorrhage with abscess formation and sepsis is presented. The pathophysiology and management of such patients is described.
华氏巨球蛋白血症（WM）患者出血并发症已有相对充分的描述。这种出血素质的病理生理学很复杂，涉及凝血因子的抑制和降低以及血小板质和量的异常。WM的治疗必须针对潜在的淋巴细胞恶性肿瘤，但改善高黏滞状态和成分输血以纠正异常凝血参数将降低出血发生率。本文报告一例WM患者，其合并大肠埃希菌尿路感染，随后发生腹膜后出血并形成脓肿及败血症。文中描述了此类患者的病理生理学及处理方法。
