Swanson P E, Storm D R
J Antibiot (Tokyo). 1979 May;32(5):511-7. doi: 10.7164/antibiotics.32.511.
Octapeptin is a peptide antibiotic which affects bacterial membrane structure and selective membrane permeability for protons and potassium. The influence of octapeptin on the formation of a membrane potential generated across bacterial vesicles was monitored using the Rb+-valinomycin transport system. Octapeptin inhibited the respiratory-linked generation of membrane potentials formed in the presence of succinate or Asc/PMS. In addition, the antibiotic inhibited [3H]-leucine transport driven either by succinate or Asc/PMS. These studies support the proposal that the antimicrobial activity of octapeptin is due to inhibition of the formation of a membrane potential generated in the presence of appropriate respiratory substrates.
八肽菌素是一种肽类抗生素，它会影响细菌膜结构以及质子和钾的选择性膜通透性。利用铷离子-缬氨霉素转运系统监测了八肽菌素对跨细菌囊泡产生的膜电位形成的影响。八肽菌素抑制了在琥珀酸盐或抗坏血酸/吩嗪硫酸甲酯存在下形成的与呼吸相关的膜电位。此外，该抗生素还抑制了由琥珀酸盐或抗坏血酸/吩嗪硫酸甲酯驱动的[3H]-亮氨酸转运。这些研究支持了这样一种观点，即八肽菌素的抗菌活性是由于抑制了在适当呼吸底物存在下产生的膜电位的形成。
