Mimura K
Nihon Seikeigeka Gakkai Zasshi. 1985 Aug;59(8):751-61.
This report presents clinical pictures of 11 patients with Paget's disease of bone treated at our clinic since 1977 and discusses the disease progress in seven patients who were given Elcatonin and EHDP and followed-up for a mean period of four years and eight months. All the patients responded to the drugs and the main clinical effect was disappearance of pain. They did not develop side effects which were especially a problem. Although both of the drugs exerted excellent effect on Paget's disease of bone, they have both strong and weak points with respect to administration route and side effects. These drugs should be selected with combined therapy, clinical effectiveness, side effects and other factors taken into account. Bone scintigram, serum alkaline phosphatase and urinary hydroxyproline were employed as therapeutic effect of these drugs. However, their handiness and reliability were unsatisfactory. More convenient parameters reflecting the disease activity more accurately are needed.
本报告展示了自1977年以来在我们诊所接受治疗的11例骨Paget病患者的临床病例，并讨论了7例接受降钙素和依替膦酸二钠治疗且平均随访4年8个月的患者的疾病进展情况。所有患者对药物均有反应，主要临床效果为疼痛消失。他们未出现特别严重的副作用问题。尽管这两种药物对骨Paget病均有显著疗效，但在给药途径和副作用方面各有优缺点。选择这些药物时应综合考虑联合治疗、临床疗效、副作用等因素。骨闪烁显像、血清碱性磷酸酶和尿羟脯氨酸被用作这些药物的治疗效果指标。然而，它们的便利性和可靠性并不令人满意。需要更方便且能更准确反映疾病活动的指标。
