Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.
Development. 2024 Oct 15;151(20). doi: 10.1242/dev.203077. Epub 2024 Oct 4.
Humans are curious to understand the causes of traits that distinguish us from other animals and that distinguish vastly different species from one another. We also have a proclivity for simple stories and sometimes tend toward seeking and accepting simple genetic explanations for large evolutionary shifts, even to a single gene. Here, I reveal how a biased expectation of mechanistic simplicity threads through the long history of evolutionary and developmental genetics. I argue, however, that expecting a simple mechanism threatens a deeper understanding of evolution, and I define the limitations for interpreting experimental evidence in evolutionary developmental genetics.
人类渴望了解使我们有别于其他动物的特征的原因,也渴望了解使截然不同的物种彼此相异的原因。我们还倾向于接受简单的故事,有时甚至会寻找并接受单一基因对于大型进化转变的简单遗传解释。在这里,我揭示了机械简单性的偏见期望如何贯穿进化和发育遗传学的悠久历史。然而,我认为期望一个简单的机制会威胁到对进化的更深入理解,并定义了在进化发育遗传学中解释实验证据的局限性。