Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, Shaanxi, 710069, PR China; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, 710069, PR China.
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 311402, Hangzhou, PR China.
Eur J Med Chem. 2024 Dec 15;280:116931. doi: 10.1016/j.ejmech.2024.116931. Epub 2024 Oct 1.
Carbon dots (CDs) exhibit great potential in medicinal chemistry due to its excellent optical properties, biocompatibility and scalability, which have attracted significant interest. Based on their specific synthesis and modification, this review provided an overview of the evolution of the synthesis of CDs and reviewed the discovery and development of their optical properties. This review examines recent advances of CDs in medicinal chemistry, with a particular focus on the use of CDs as drugs and carriers for photodynamic and photothermal therapies in the field of neurological disorders, cancer, bacterial, viral, and further in combination with imaging for diagnostic and therapeutic integration. Finally, this review addresses the challenges and limitations of CDs in medicinal chemistry. This review provides a comprehensive overview of the development process of CDs and their applications in various aspects of medicinal chemistry, thereby offers insights to the development of CDs in the field of medicinal chemistry.
碳点（CDs）由于其优异的光学性质、生物相容性和可扩展性，在药物化学中具有巨大的潜力，引起了人们的极大关注。本综述根据其特定的合成和修饰方法，综述了 CDs 的合成演变，并回顾了其光学性质的发现和发展。本综述考察了 CDs 在药物化学中的最新进展，特别关注了 CDs 作为药物和载体在神经紊乱、癌症、细菌、病毒等领域的光动力和光热治疗中的应用，以及与成像技术的进一步结合，用于诊断和治疗的一体化。最后，本综述讨论了 CDs 在药物化学中的挑战和局限性。本综述全面概述了 CDs 的发展过程及其在药物化学各个方面的应用，为 CDs 在药物化学领域的发展提供了思路。
