Müller W, von der Hardt H
Monatsschr Kinderheilkd. 1985 Dec;133(12):882-6.
The effect of a long-term drug therapy in childhood asthma was investigated in all children seen in our outpatient clinic for the first time in 1981 and followed over the next two years. The drug schedule consisted of a step-wise increasing medication with regard to severity and form of bronchial asthma. Most children of grades II to IV improved during the study period. Children with rarely occurring episodes of asthma (grade I) received therapy only during asthmatic episodes and did not improve. The results of this study are discussed with respect to the natural course of the disease and immunotherapy (hyposensitization).
1981年首次到我们门诊就诊并在接下来两年进行随访的所有儿童，都接受了针对儿童哮喘长期药物治疗效果的调查。药物治疗方案是根据支气管哮喘的严重程度和类型逐步增加用药剂量。在研究期间，大多数II至IV级的儿童病情有所改善。哮喘发作很少（I级）的儿童仅在哮喘发作期间接受治疗，病情未见改善。本研究结果将结合该疾病的自然病程和免疫疗法（减敏疗法）进行讨论。
