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《结构材料蓝图：组织工程用超材料设计指南》。

Blueprints of Architected Materials: A Guide to Metamaterial Design for Tissue Engineering.

机构信息

Complex Tissue Regeneration Department, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.

Division of Pharmacology, Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, Utrecht, 3584 CG, The Netherlands.

出版信息

Adv Mater. 2024 Nov;36(47):e2408082. doi: 10.1002/adma.202408082. Epub 2024 Oct 6.

DOI:10.1002/adma.202408082
PMID:39370588
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11586834/
Abstract

Mechanical metamaterials are rationally designed structures engineered to exhibit extraordinary properties, often surpassing those of their constituent materials. The geometry of metamaterials' building blocks, referred to as unit cells, plays an essential role in determining their macroscopic mechanical behavior. Due to their hierarchical design and remarkable properties, metamaterials hold significant potential for tissue engineering; however their implementation in the field remains limited. The major challenge hindering the broader use of metamaterials lies in the complexity of unit cell design and fabrication. To address this gap, a comprehensive guide is presented detailing the design principles of well-established metamaterials. The essential unit cell geometric parameters and design constraints, as well as their influence on mechanical behavior, are summarized highlighting essential points for effective fabrication. Moreover, the potential integration of artificial intelligence techniques is explored in meta-biomaterial design for patient- and application-specific design. Furthermore, a comprehensive overview of current applications of mechanical metamaterials is provided in tissue engineering, categorized by tissue type, thereby showcasing the versatility of different designs in matching the mechanical properties of the target tissue. This review aims to provide a valuable resource for tissue engineering researchers and aid in the broader use of metamaterials in the field.

摘要

机械超材料是经过精心设计的结构，旨在展现出非凡的性能，这些性能往往超越了组成它们的材料。超材料的构建块的几何形状，即单元胞，在决定其宏观力学行为方面起着至关重要的作用。由于其分层设计和显著的性能，超材料在组织工程中有很大的应用潜力；然而，它们在该领域的应用仍然有限。阻碍超材料更广泛应用的主要挑战在于单元胞设计和制造的复杂性。为了解决这一差距，本文详细介绍了经过充分验证的超材料的设计原则，提供了全面的指南。总结了基本单元胞几何参数和设计约束及其对力学行为的影响，突出了有效制造的要点。此外，还探讨了在针对患者和应用的特定设计中，人工智能技术在元生物材料设计中的潜在应用。此外，还全面概述了机械超材料在组织工程中的当前应用，按组织类型进行分类，展示了不同设计在匹配目标组织力学性能方面的多功能性。本文旨在为组织工程研究人员提供有价值的资源，并帮助超材料在该领域得到更广泛的应用。

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