Kouraki Afroditi, Vijay Amrita, Gohir Sameer, Millar Bonnie, Kelly Anthony, Valdes Ana M
Academic Unit of Injury, Recovery and Inflammation Sciences, Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK.
NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.
Sports Health. 2024 Oct 6:19417381241283812. doi: 10.1177/19417381241283812.
Aerobic exercise alters gut microbiome composition, yet the impact of gentle physiotherapy on gut microbiome and its relation to muscle strengthening and physical function remains unexplored.
Physiotherapy exercises modulate gut microbiome composition and changes in gut microbes are linked to improvements in muscle strength or function.
Secondary data analysis of samples from a randomized controlled trial.
Level 2b.
Data from a 6-week randomized controlled trial of physiotherapy for knee pain were analyzed. Gut microbiota profiling utilized 16S sequencing. We compared intervention and control (usual care) groups using microbial diversity metrics. Amplicon sequence variants (ASVs) that changed after the program were identified with ALDEX2, and correlations between these ASVs and measures of physical function, muscle strength, and interleukin-6 (IL-6) were explored.
No diversity changes were observed between standard care (n = 43) and physiotherapy (n = 34). Physiotherapy led to significant increases in , , , and ASVs. Of these, and were associated with postintervention muscle strength. Increase in was correlated with a decrease in IL-6 in the physiotherapy group.
Physiotherapy had modest effects on gut microbiome composition affecting 4 taxa. Increases in muscle strength were correlated with increases in 2 taxa including was also linked to reduced inflammation. Improved walking speed was linked to an increase in with no differences found for strength or squatting ability.
Improved gut microbiome composition is linked to better overall health outcomes, including enhanced immune function, reduced inflammation, and improved metabolic health. This is particularly relevant for patients with osteoarthritis, who are known to have a high prevalence of cardiometabolic comorbidities. Integrating physiotherapy protocols that positively influence the gut microbiome can thus enhance overall patient outcomes.
有氧运动可改变肠道微生物群组成，但温和的物理治疗对肠道微生物群的影响及其与肌肉强化和身体功能的关系仍未得到探索。
物理治疗运动可调节肠道微生物群组成，且肠道微生物的变化与肌肉力量或功能的改善有关。
对一项随机对照试验的样本进行二次数据分析。
2b级。
分析了一项为期6周的膝关节疼痛物理治疗随机对照试验的数据。肠道微生物群分析采用16S测序。我们使用微生物多样性指标比较了干预组和对照组（常规护理）。使用ALDEX2识别项目后发生变化的扩增子序列变体（ASV），并探索这些ASV与身体功能、肌肉力量和白细胞介素-6（IL-6）测量值之间的相关性。
在标准护理组（n = 43）和物理治疗组（n = 34）之间未观察到多样性变化。物理治疗导致 、 、 和 ASV显著增加。其中， 和 与干预后的肌肉力量相关。 在物理治疗组中的增加与IL-6的减少相关。
物理治疗对影响4个分类群的肠道微生物群组成有适度影响。肌肉力量的增加与2个分类群的增加相关，包括 也与炎症减轻有关。步行速度的提高与 的增加有关，在力量或蹲坐能力方面未发现差异。
改善肠道微生物群组成与更好的整体健康结果相关，包括增强免疫功能、减轻炎症和改善代谢健康。这对骨关节炎患者尤为重要，已知他们心血管代谢合并症的患病率很高。因此，整合对肠道微生物群有积极影响的物理治疗方案可以提高患者的整体治疗效果。
