Department of General Practice, Erasmus MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, Netherlands.
Department of Medical Informatics, Erasmus MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, Netherlands.
Arthritis Res Ther. 2023 Jul 4;25(1):114. doi: 10.1186/s13075-023-03086-8.
Comorbidities are common in patients with osteoarthritis (OA). This study aimed to determine the association of a wide range of previously diagnosed comorbidities in adults with newly diagnosed OA compared with matched controls without OA.
A case-control study was conducted. The data were derived from an electronic health record database that contains the medical records of patients from general practices throughout the Netherlands. Incident OA cases were defined as patients with one or more diagnostic codes recorded in their medical records that correspond to knee, hip, or other/peripheral OA. Additionally, the first OA code had to be recorded between January 1, 2006, and December 31, 2019. The date of cases' first OA diagnosis was defined as the index date. Cases were matched (by age, sex, and general practice) to up to 4 controls without a recorded OA diagnosis. Odds ratios were derived for each 58 comorbidities separately by dividing the comorbidity prevalence of cases by that of their matched controls at the index date.
80,099 incident OA patients were identified of whom 79,937 (99.8%) were successfully matched with 318,206 controls. OA cases had higher odds for 42 of the 58 studied comorbidities compared with matched controls. Musculoskeletal diseases and obesity showed large associations with incident OA.
Most of the comorbidities under study had higher odds in patients with incident OA at the index date. While previously known associations were confirmed in this study, some associations were not described earlier.
合并症在骨关节炎（OA）患者中很常见。本研究旨在确定与未患 OA 的匹配对照者相比，广泛诊断的成年人合并症与新诊断的 OA 之间的关联。
进行了病例对照研究。该数据来自电子健康记录数据库，其中包含荷兰各地普通诊所患者的病历。新诊断的 OA 病例定义为其病历中记录有一个或多个与膝关节、髋关节或其他/外周性 OA 相对应的诊断代码的患者。此外，第一个 OA 代码必须在 2006 年 1 月 1 日至 2019 年 12 月 31 日之间记录。病例的首次 OA 诊断日期定义为索引日期。通过按年龄、性别和普通诊所将每个病例与多达 4 名未记录 OA 诊断的对照者进行匹配。将病例的合并症患病率除以其在索引日期的匹配对照者的合并症患病率，分别为每种 58 种合并症计算比值比。
确定了 80099 例新诊断的 OA 患者，其中 79937 例（99.8%）成功匹配了 318206 例对照者。与匹配对照者相比，OA 病例发生 42 种研究合并症的可能性更高。肌肉骨骼疾病和肥胖与新发 OA 具有较大的相关性。
在索引日期患有新发 OA 的患者中，大多数研究的合并症发生的可能性更高。虽然本研究证实了先前已知的关联，但也有一些关联以前并未描述过。
