REQUIMTE/LAQV, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Laboratory of Pharmaceutical Technology, Faculty of Pharmacy of University of Porto, Porto, Portugal.
Expert Opin Drug Deliv. 2024 Oct;21(10):1479-1490. doi: 10.1080/17425247.2024.2410951. Epub 2024 Oct 7.
Nanoparticles (NPs) are widely used in the pharmaceutical field to treat various human disorders. Among these, lipid-based NPs (LNPs), including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), are favored for drug/bioactive delivery due to their high stability, biocompatibility, encapsulation efficiency, and sustained/controlled release. These properties make them particularly suitable as carriers of compounds derived from plant sources.
This study comprehensively explores updated literature knowledge on SLN and NLC, focusing on their composition and production methods for the specific delivery of drug/bioactive compounds derived from plant sources of interest in pharmaceutical and biomedical fields.
SLN and NLC facilitate the development of more effective natural product-based therapies, aiming to reduce dosage and minimize side effects. These delivery systems align with the consumer demands for safer and more sustainable products, as there are also based on biocompatible and biodegradable raw materials, thereby posing minimal toxicological risks while also meeting regulatory guidelines.
纳米粒子（NPs）广泛应用于制药领域，以治疗各种人类疾病。在这些纳米粒子中，基于脂质的 NPs（LNPs），包括固体脂质纳米粒（SLN）和纳米结构脂质载体（NLC），由于其高稳定性、生物相容性、包封效率和持续/控制释放，被认为是药物/生物活性物质传递的理想载体。这些特性使它们特别适合作为植物源化合物的载体。
本研究全面探讨了关于 SLN 和 NLC 的最新文献知识，重点介绍了它们的组成和生产方法，用于特定传递药物/生物活性化合物，这些化合物来源于制药和生物医学领域中感兴趣的植物源。
SLN 和 NLC 促进了更有效的基于天然产物的治疗方法的发展，旨在减少剂量并最小化副作用。这些递药系统符合消费者对更安全和更可持续产品的需求，因为它们还基于生物相容性和可生物降解的原料，从而在满足监管指南的同时，最大限度地降低了毒理学风险。
