Huang Qiuwei, Lou Chenhao, Lv Leiyang, Li Zhiping
Key Laboratory of Advanced Light Conversion Materials and Biophotonics, School of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China.
Chem Commun (Camb). 2024 Oct 22;60(85):12389-12392. doi: 10.1039/d4cc04650a.
We report here a photoinduced iron-catalyzed fluoroalkylation-peroxidation of activated and/or unactivated alkenes with fluoroalkyl carboxylic acids and hydroperoxide. The ligand-to-iron charge transfer strategy effectively overcomes the high redox potential of the fluoroalkyl carboxylic acids, facilitating the difunctionalization reaction to occur smoothly under mild reaction conditions. The late-stage functionalization of drug and natural product derivatives was also demonstrated.
我们在此报告一种光诱导铁催化的、使活化和/或未活化烯烃与氟代烷基羧酸和氢过氧化物发生氟烷基化-过氧化反应的方法。配体到铁的电荷转移策略有效克服了氟代烷基羧酸的高氧化还原电位，促使双官能化反应在温和的反应条件下顺利发生。同时还展示了药物和天然产物衍生物的后期官能化。
