Dascǎlu Rucsandra Cristina, Bǎrbulescu Andreea Lili, Dinescu Ştefan Cristian, Bițǎ Cristina Elena, Stoica Loredana Elena, Sandu Raluca Elena, Vreju Florentin Ananu
PhD Student, University of Medicine and Pharmacy of Craiova, Romania.
Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.
Curr Health Sci J. 2024 Apr-Jun;50(2):215-222. doi: 10.12865/CHSJ.50.02.06. Epub 2024 Jun 30.
Our observational study included on 54 patients with PsO, evaluated into the Dermatology Department of the Emergency County Hospital Craiova, Romania, between August 2023 and January 2024, and 40 controls. Our research proposed determining the prevalence of MetS in a cohort of PsO patients, and its relationship to subclinical atherosclerosis, evaluated by carotid ultrasound. Metabolic syndrome (MetS) was established according to National Cholesterol Education Program (NCP) Adult Treatment Panel (ATP) III criteria for MetS for 35 of the patients (64.81%) vs. 11 of the control group (27.5%), p=0.0003. An overview of each component of MetS depending on the diagnostic criteria for MetS showed that waist and total cholesterol exerted significant differences. Carotid ultrasound evaluation revealed an increased ITM, of over 0.9mm, for 19 (35.18%) or PsO patients, significantly increased compared to controls, as well as the presence of carotid plaques in significantly different percentages (37.03% PsO vs. 17.5% controls, p=0.001). We also noted that for patients with MetS, US examination displayed increased results for IMT compared to those without MetS. The prevalence of carotid atheroma plaque was augmented in patients with MetS and PsO. In our PsO group IMT exerted a positive inter-relation with: age, MetS, blood glucose, disease duration, and PASI. Important to note is that after multiple linear regression analysis, age and MetS were independent indicators of IMT (p=0.02 for age and p=0.001 for MetS). Our findings sustain a firm relationship between MetS and psoriasis and the major consequence of this observation is the inherent risk of cardiovascular events.
我们的观察性研究纳入了2023年8月至2024年1月期间在罗马尼亚克拉约瓦县急诊医院皮肤科就诊的54例银屑病关节炎（PsO）患者以及40例对照。我们的研究旨在确定PsO患者队列中代谢综合征（MetS）的患病率及其与通过颈动脉超声评估的亚临床动脉粥样硬化的关系。根据美国国家胆固醇教育计划（NCEP）成人治疗小组（ATP）III的MetS标准，35例患者（64.81%）被诊断为MetS，而对照组中有11例（27.5%），p = 0.0003。根据MetS诊断标准对MetS各组成部分的概述显示，腰围和总胆固醇存在显著差异。颈动脉超声评估显示，19例（35.18%）PsO患者的内膜中层厚度（IMT）增加超过0.9mm，与对照组相比显著增加，同时颈动脉斑块的存在比例也有显著差异（PsO组为37.03%，对照组为17.5%，p = 0.001）。我们还注意到，与无MetS的患者相比，有MetS的患者超声检查显示IMT结果更高。MetS和PsO患者中颈动脉粥样斑块的患病率增加。在我们的PsO组中，IMT与年龄、MetS、血糖、病程和银屑病面积和严重程度指数（PASI）呈正相关。需要注意的是，经过多元线性回归分析后，年龄和MetS是IMT的独立指标（年龄p = 0.02，MetS p = 0.001）。我们的研究结果证实了MetS与银屑病之间的紧密关系，这一观察结果的主要后果是存在心血管事件的内在风险。
