Saunders W, Castro J R, Chen G T, Collier J M, Zink S R, Pitluck S, Phillips T L, Char D, Gutin P, Gauger G
Radiat Res Suppl. 1985;8:S227-34.
We report on the first decade of the helium-ion radiotherapy clinical trial being carried out at the Lawrence Berkeley Laboratory. Over 500 patients have now been treated. We have had very good results to date in treating patients with small tumors critically located near a radiation-sensitive organ which would preclude delivering a curative dose with conventional radiotherapy. On the other hand, patients with larger tumors where the tumor dose cannot be increased more than 10% over conventional radiotherapy have not responded well to helium ion radiotherapy. This is illustrated by discussing selected patient groups in detail, namely those with uveal melanoma, small, low-grade tumors near the central nervous system, carcinoma of the pancreas, and carcinoma of the esophagus.
我们报告了劳伦斯伯克利实验室正在进行的氦离子放射治疗临床试验的第一个十年。目前已有500多名患者接受了治疗。迄今为止，在治疗位于对辐射敏感器官附近的小肿瘤患者方面，我们取得了非常好的效果，而这些小肿瘤若采用传统放射治疗则无法给予治愈剂量。另一方面，对于肿瘤较大且肿瘤剂量无法比传统放射治疗增加超过10%的患者，氦离子放射治疗的效果不佳。通过详细讨论选定的患者群体，即葡萄膜黑色素瘤患者、中枢神经系统附近的小的低级别肿瘤患者、胰腺癌患者和食管癌患者，可说明这一点。
