德国离子束治疗的历史。

Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT) at the University Hospital Heidelberg, Heidelberg, Germany; National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany.

Department of Biophysics, Helmholtz Center for Heavy Ion Research (GSI), Darmstadt, Germany.

Z Med Phys. 2022 Feb;32(1):6-22. doi: 10.1016/j.zemedi.2021.11.003. Epub 2022 Jan 31.

The advantageous depth dose profile of ion beams together with state of the art beam delivery and treatment planning systems allow for highly conformal tumor treatments in patients. First treatments date back to 1954 at the Lawrence Berkeley Laboratory (LBL) and in Europe, ion beam therapy started in the mid-1990s at the Paul-Scherrer Institute (PSI) with protons and at the Helmholtz Center for Heavy Ion Research (GSI) with carbon ions, followed by the Heidelberg Ion Therapy Center (HIT) in Heidelberg. This review describes the historical development of ion beam therapy in Germany based on the pioneering work at LBL and in the context of simultaneous developments in other countries as well as recent developments.

离子束的优势深度剂量分布，加上先进的束流输送和治疗计划系统，使得对患者进行高适形肿瘤治疗成为可能。最早的治疗可以追溯到 1954 年在劳伦斯伯克利国家实验室（LBL），在欧洲，离子束治疗始于 20 世纪 90 年代中期，在保罗谢勒研究所（PSI）用质子治疗，在重离子研究中心（GSI）用碳离子治疗，随后是海德堡离子治疗中心（HIT）。本综述基于 LBL 的开创性工作，结合其他国家的同时发展以及最近的发展，描述了德国离子束治疗的历史发展。