• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫功能低下宿主中的持续性新冠病毒感染：一例报告

Persistent COVID-19 Infection in an Immunocompromised Host: A Case Report.

作者信息

Das Rashmita, Karyakarte Rajesh P, Joshi Suvarna, Joy Marie, Sadre Abhay

机构信息

Microbiology, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, IND.

Nephrology, Ruby Hall Clinic, Pune, IND.

出版信息

Cureus. 2024 Sep 4;16(9):e68679. doi: 10.7759/cureus.68679. eCollection 2024 Sep.

DOI:10.7759/cureus.68679
PMID:39371780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11452762/
Abstract

This case report highlights the prolonged SARS-CoV-2 reverse transcriptase polymerase chain reaction positivity in a 32-year-old immunocompromised male with a history of kidney transplants and chronic kidney disease. The whole genome sequencing of nasopharyngeal samples for SARS-CoV-2 collected 12 days apart showed the presence of the BA.1.1 Omicron variant. It revealed evidence of intra-host viral evolution, showing the development and loss of specific mutations over time. This report emphasizes the need for continuous monitoring strategies for immunocompromised patients, as they may serve as reservoirs for viral evolution and potentially give rise to immune escape variants.

摘要

本病例报告强调了一名32岁免疫功能低下男性（有肾移植和慢性肾病病史）的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）逆转录酶聚合酶链反应（RT-PCR）阳性持续时间延长。相隔12天采集的SARS-CoV-2鼻咽样本的全基因组测序显示存在BA.1.1奥密克戎变异株。它揭示了宿主内病毒进化的证据，表明特定突变随时间的发展和消失。本报告强调了对免疫功能低下患者采取持续监测策略的必要性，因为他们可能成为病毒进化的储存库，并可能产生免疫逃逸变异株。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df63/11452762/a2efc0c69ae5/cureus-0016-00000068679-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df63/11452762/fba211fb109e/cureus-0016-00000068679-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df63/11452762/98ef10976d07/cureus-0016-00000068679-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df63/11452762/a2efc0c69ae5/cureus-0016-00000068679-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df63/11452762/fba211fb109e/cureus-0016-00000068679-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df63/11452762/98ef10976d07/cureus-0016-00000068679-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df63/11452762/a2efc0c69ae5/cureus-0016-00000068679-i03.jpg

相似文献

1
Persistent COVID-19 Infection in an Immunocompromised Host: A Case Report.免疫功能低下宿主中的持续性新冠病毒感染：一例报告
Cureus. 2024 Sep 4;16(9):e68679. doi: 10.7759/cureus.68679. eCollection 2024 Sep.
2
Emergence of SARS-CoV-2 Spike Mutations during Prolonged Infection in Immunocompromised Hosts.免疫功能低下宿主体内 SARS-CoV-2 刺突突变的长期感染中出现。
Microbiol Spectr. 2022 Jun 29;10(3):e0079122. doi: 10.1128/spectrum.00791-22. Epub 2022 May 11.
3
Resurgence of SARS-CoV-2 Delta after Omicron variant superinfection in an immunocompromised pediatric patient.奥密克戎变异株超感染后免疫功能低下的儿科患者中 SARS-CoV-2 Delta 的再现。
Virol J. 2023 Oct 27;20(1):246. doi: 10.1186/s12985-023-02186-w.
4
Effect of molnupiravir on SARS-CoV-2 evolution in immunocompromised patients: a retrospective observational study.莫努匹韦对免疫功能低下患者中 SARS-CoV-2 进化的影响：一项回顾性观察研究。
Lancet Microbe. 2024 May;5(5):e452-e458. doi: 10.1016/S2666-5247(23)00393-2. Epub 2024 Mar 22.
5
Case reports of persistent SARS-CoV-2 infection outline within-host viral evolution in immunocompromised patients.病例报告显示，免疫功能低下患者的 SARS-CoV-2 持续感染概述了体内病毒进化。
Virol J. 2024 Sep 3;21(1):210. doi: 10.1186/s12985-024-02483-y.
6
SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient.一名免疫功能低下患者长期感染期间的SARS-CoV-2宿主内进化
Int J Infect Dis. 2022 Sep;122:444-448. doi: 10.1016/j.ijid.2022.06.023. Epub 2022 Jun 18.
7
A case of SARS-CoV-2 Omicron reinfection resulting in a significant immunity boost in a paediatric patient affected by B-cell acute lymphoblastic leukemia.奥密克戎变异株再感染 1 例：对 1 例伴 B 细胞急性淋巴细胞白血病的儿科患者产生显著免疫增强作用
BMC Infect Dis. 2023 Mar 7;23(1):133. doi: 10.1186/s12879-023-08111-4.
8
Rapid Selection of Sotrovimab Escape Variants in Severe Acute Respiratory Syndrome Coronavirus 2 Omicron-Infected Immunocompromised Patients.严重急性呼吸综合征冠状病毒 2 型奥密克戎感染免疫功能低下患者中索托维单抗逃逸变异的快速选择。
Clin Infect Dis. 2023 Feb 8;76(3):408-415. doi: 10.1093/cid/ciac802.
9
[P323L Mutation in a Case with Prolonged SARS-CoV-2 PCR Positivity].[一例新冠病毒核酸检测长期呈阳性病例中的P323L突变]
Mikrobiyol Bul. 2023 Jul;57(3):490-497. doi: 10.5578/mb.20239941.
10
Isolation of SARS-CoV-2 in Viral Cell Culture in Immunocompromised Patients With Persistently Positive RT-PCR Results.免疫功能低下的持续性 RT-PCR 阳性结果患者的病毒细胞培养中 SARS-CoV-2 的分离。
Front Cell Infect Microbiol. 2022 Feb 2;12:804175. doi: 10.3389/fcimb.2022.804175. eCollection 2022.

引用本文的文献

1
Monitoring Influenza A (H1N1, H3N2), RSV, and SARS-CoV-2 Using Wastewater-Based Epidemiology: A 2-Year Longitudinal Study in an Indian Megacity Covering Omicron and Post-Omicron Phases.利用基于污水的流行病学监测甲型流感 (H1N1、H3N2)、呼吸道合胞病毒和 SARS-CoV-2：在印度特大城市进行的一项为期 2 年的纵向研究，涵盖了奥密克戎和奥密克戎后阶段。
Food Environ Virol. 2024 Nov 19;17(1):3. doi: 10.1007/s12560-024-09618-y.

本文引用的文献

1
Using big sequencing data to identify chronic SARS-Coronavirus-2 infections.利用大测序数据识别慢性严重急性呼吸系统综合征冠状病毒 2 感染。
Nat Commun. 2024 Jan 20;15(1):648. doi: 10.1038/s41467-024-44803-4.
2
Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy.单克隆抗体治疗产生的 SARS-CoV-2 逃逸突变。
Nat Commun. 2023 Jun 7;14(1):3334. doi: 10.1038/s41467-023-37826-w.
3
Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments.宿主免疫反应促进接受单克隆抗体治疗的患者中 SARS-CoV-2 突变的发展。
J Clin Invest. 2023 Mar 15;133(6):e166032. doi: 10.1172/JCI166032.
4
Correction to: The origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 in the UK.对《英国SARS-CoV-2谱系B.1.1.7的起源和分子进化》的更正
Virus Evol. 2022 Dec 30;8(2):veac119. doi: 10.1093/ve/veac119. eCollection 2022.
5
Structural Landscape of nsp Coding Genomic Regions of SARS-CoV-2-ssRNA Genome: A Structural Genomics Approach Toward Identification of Druggable Genome, Ligand-Binding Pockets, and Structure-Based Druggability.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）单链RNA基因组nsp编码基因组区域的结构全景：一种基于结构基因组学的方法，用于识别可成药基因组、配体结合口袋和基于结构的可成药性。
Mol Biotechnol. 2024 Apr;66(4):641-662. doi: 10.1007/s12033-022-00605-x. Epub 2022 Dec 4.
6
SARS-CoV-2 viral load and shedding kinetics.SARS-CoV-2 病毒载量和脱落动力学。
Nat Rev Microbiol. 2023 Mar;21(3):147-161. doi: 10.1038/s41579-022-00822-w. Epub 2022 Dec 2.
7
Persistent SARS-CoV-2 infection in immunocompromised patients facilitates rapid viral evolution: Retrospective cohort study and literature review.免疫功能低下患者中持续的SARS-CoV-2感染促进病毒快速进化：回顾性队列研究与文献综述
Clin Infect Pract. 2022 Nov;16:100210. doi: 10.1016/j.clinpr.2022.100210. Epub 2022 Nov 16.
8
Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study.与 COVID-19 轻症和中度患者 RT-PCR SARS-CoV-2 检测阳性时间延长相关因素：一项回顾性研究。
Medicina (Kaunas). 2022 May 26;58(6):707. doi: 10.3390/medicina58060707.
9
SARS-CoV-2 Evolution and Immune Escape in Immunocompromised Patients.免疫功能低下患者中SARS-CoV-2的进化与免疫逃逸
N Engl J Med. 2022 Jun 23;386(25):2436-2438. doi: 10.1056/NEJMc2202861. Epub 2022 Jun 8.
10
SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape.在晚期 HIV 疾病中，SARS-CoV-2 持续感染会导致广泛的免疫逃逸。
Cell Host Microbe. 2022 Feb 9;30(2):154-162.e5. doi: 10.1016/j.chom.2022.01.005. Epub 2022 Jan 14.