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使用光相干断层扫描血管造影术定量分析健康和梗死大鼠心脏的微血管结构。

Quantifying Microvascular Structure in Healthy and Infarcted Rat Hearts Using Optical Coherence Tomography Angiography.

出版信息

IEEE Trans Med Imaging. 2024 Aug;43(8):2878-2887. doi: 10.1109/TMI.2024.3381934. Epub 2024 Aug 1.

DOI:10.1109/TMI.2024.3381934
PMID:38568757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11341234/
Abstract

Myocardial infarction (MI) is a life-threatening medical emergency resulting in coronary microvascular dysregulation and heart muscle damage. One of the primary characteristics of MI is capillary loss, which plays a significant role in the progression of this cardiovascular condition. In this study, we utilized optical coherence tomography angiography (OCTA) to image coronary microcirculation in fixed rat hearts, aiming to analyze coronary microvascular impairment post-infarction. Various angiographic metrics are presented to quantify vascular features, including the vessel area density, vessel complexity index, vessel tortuosity index, and flow impairment. Pathological differences identified from OCTA analysis are corroborated with histological analysis. The quantitative assessments reveal a significant decrease in microvascular density in the capillary-sized vessels and an enlargement for the arteriole/venule-sized vessels. Further, microvascular tortuosity and complexity exhibit an increase after myocardial infarction. The results underscore the feasibility of using OCTA to offer qualitative microvascular details and quantitative metrics, providing insights into coronary vascular network remodeling during disease progression and response to therapy.

摘要

心肌梗死（MI）是一种危及生命的医疗紧急情况，导致冠状动脉微血管调节紊乱和心肌损伤。MI 的主要特征之一是毛细血管丧失，这在这种心血管疾病的进展中起着重要作用。在这项研究中，我们利用光学相干断层扫描血管造影（OCTA）对固定大鼠心脏的冠状动脉微循环进行成像，旨在分析梗死后冠状动脉微血管损伤。提出了各种血管造影指标来量化血管特征，包括血管面积密度、血管复杂度指数、血管迂曲指数和血流损伤。OCTA 分析中识别的病理差异与组织学分析相吻合。定量评估显示毛细血管大小的血管中的微血管密度显著降低，而小动脉/小静脉大小的血管增大。此外，心肌梗死后微血管迂曲和复杂性增加。研究结果强调了 OCTA 用于提供定性微血管细节和定量指标的可行性，为疾病进展过程中冠状动脉血管网络重塑以及对治疗的反应提供了深入了解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/94437677d23c/nihms-2014228-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/ac94a38ade2d/nihms-2014228-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/4b8694f28945/nihms-2014228-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/daf392f7a222/nihms-2014228-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/76f9583e66a1/nihms-2014228-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/89dc3f8320d2/nihms-2014228-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/e7c0ba35faaa/nihms-2014228-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/1078eefccc1e/nihms-2014228-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/2903e18c0233/nihms-2014228-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/7a4a61ff4f80/nihms-2014228-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/94437677d23c/nihms-2014228-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/ac94a38ade2d/nihms-2014228-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/4b8694f28945/nihms-2014228-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/daf392f7a222/nihms-2014228-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/76f9583e66a1/nihms-2014228-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/89dc3f8320d2/nihms-2014228-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/e7c0ba35faaa/nihms-2014228-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/1078eefccc1e/nihms-2014228-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/2903e18c0233/nihms-2014228-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/7a4a61ff4f80/nihms-2014228-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d3/11341234/94437677d23c/nihms-2014228-f0010.jpg

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